タイトル | Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. |
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ジャーナル・号・ページ | Sci Rep, Vol. 10, Page 12027-12027, Year 2020 |
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掲載日 | 2020年5月29日 (構造データの登録日) |
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著者 | Vann, K.R. / Pal, D. / Morales, G.A. / Burgoyne, A.M. / Durden, D.L. / Kutateladze, T.G. |
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リンク | Sci Rep / PubMed:32694708 |
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手法 | X線回折 |
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解像度 | 1.951 - 2.7 Å |
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構造データ | PDB-6x7b: BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212P 手法: X-RAY DIFFRACTION / 解像度: 1.951 Å PDB-6x7c: BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-6x7d: BRD4 Bromodomain 1 in complex with multi-action inhibitor SF2523P 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
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化合物 | ChemComp-ZVP: 7-[7-oxo-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide
ChemComp-KV9: 7-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide
ChemComp-UT4: 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-7-one
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSCRIPTION / BRD4 / PI3K / CDK4/6 |
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