タイトル | STING cyclic dinucleotide sensing originated in bacteria. |
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ジャーナル・号・ページ | Nature, Vol. 586, Page 429-433, Year 2020 |
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掲載日 | 2020年5月1日 (構造データの登録日) |
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著者 | Morehouse, B.R. / Govande, A.A. / Millman, A. / Keszei, A.F.A. / Lowey, B. / Ofir, G. / Shao, S. / Sorek, R. / Kranzusch, P.J. |
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リンク | Nature / PubMed:32877915 |
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手法 | X線回折 |
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解像度 | 1.52 - 2.9 Å |
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構造データ | PDB-6wt4: Structure of a bacterial STING receptor from Flavobacteriaceae sp. in complex with 3',3'-cGAMP 手法: X-RAY DIFFRACTION / 解像度: 1.78 Å PDB-6wt5: Structure of a bacterial STING receptor from Capnocytophaga granulosa 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-6wt6: Structure of a metazoan TIR-STING receptor from C. gigas 手法: X-RAY DIFFRACTION / 解像度: 2.41 Å PDB-6wt7: Structure of a metazoan TIR-STING receptor from C. gigas in complex with 2',3'-cGAMP 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-6wt8: Structure of a STING-associated CdnE c-di-GMP synthase from Flavobacteriaceae sp. 手法: X-RAY DIFFRACTION / 解像度: 1.52 Å PDB-6wt9: Structure of STING-associated CdnE c-di-GMP synthase from Capnocytophaga granulosa 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å |
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化合物 | ChemComp-4BW: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one / cGAMP
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由来 | - flavobacteriaceae (バクテリア)
- capnocytophaga granulosa (バクテリア)
- crassostrea gigas (無脊椎動物)
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キーワード | IMMUNE SYSTEM / CBASS / cyclic dinucleotide receptor / CD-NTase / immune effector / TIR domain / TRANSFERASE / c-di-GMP / STING |
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