タイトル | Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box. |
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ジャーナル・号・ページ | Acs Infect Dis., Vol. 7, Page 2455-2471, Year 2021 |
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掲載日 | 2020年3月5日 (構造データの登録日) |
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著者 | Mercaldi, G.F. / Eufrasio, A.G. / Ranzani, A.T. / do Nascimento Faria, J. / Mota, S.G.R. / Fagundes, M. / Bruder, M. / Cordeiro, A.T. |
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リンク | Acs Infect Dis. / PubMed:34279922 |
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手法 | X線回折 |
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解像度 | 1.55 - 2.14 Å |
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構造データ | PDB-6w29: Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC013) 手法: X-RAY DIFFRACTION / 解像度: 2.14 Å PDB-6w2n: Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC009) 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-6w49: Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC010) 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-6w53: Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC070) 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6w56: Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC062) 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6w57: Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC069) 手法: X-RAY DIFFRACTION / 解像度: 1.78 Å PDB-6w59: Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC063) 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-7mf4: Crystal structure of Trypanosoma cruzi cytosolic Malic Enzyme 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å |
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化合物 | ChemComp-SEV: 3,5-bis(fluoranyl)-~{N}-[3-[(4-methoxyphenyl)sulfamoyl]phenyl]benzamide
ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤*YM
ChemComp-SJD: 3,5-bis(fluoranyl)-~{N}-[3-[(2-fluoranyl-4-methoxy-phenyl)sulfamoyl]phenyl]benzamide
ChemComp-SWV: ~{N}-[3-[(2-fluorophenyl)sulfamoyl]phenyl]pyrazine-2-carboxamide
ChemComp-SZP: N-(2-chloro-5-{[4-(trifluoromethoxy)phenyl]sulfamoyl}phenyl)-3,5-difluorobenzamide
ChemComp-SZJ: ~{N}-[3-[[4-[bis(fluoranyl)methoxy]phenyl]sulfamoyl]phenyl]-3,5-bis(fluoranyl)benzamide
ChemComp-SZG: ~{N}-[5-[[4-[bis(fluoranyl)methoxy]phenyl]sulfamoyl]-2-chloranyl-phenyl]-3,5-bis(fluoranyl)benzamide
ChemComp-SZD: 3,5-bis(fluoranyl)-~{N}-[3-[[4-(trifluoromethyloxy)phenyl]sulfamoyl]phenyl]benzamide
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由来 | ![](img/tx_eukaryote.gif) trypanosoma cruzi (strain cl brener) (トリパノソーマ)![](img/tx_eukaryote.gif) trypanosoma cruzi (トリパノソーマ)
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キーワード | OXIDOREDUCTASE/Inhibitor / Inhibitor / isomerase / OXIDOREDUCTASE / OXIDOREDUCTASE-Inhibitor complex / complex / cytosol |
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