Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
PDB-6w0n: Structure of KHK in complex with compound 2 手法: X-RAY DIFFRACTION / 解像度: 2.41 Å
PDB-6w0w: Structure of KHK in complex with compound 3 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å
PDB-6w0x: Structure of KHK in complex with compound 4 (6-[(1~{S},5~{R})-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]-2-[(2~{S},3~{R})-2-methyl-3-oxidanyl-azetidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile) 手法: X-RAY DIFFRACTION / 解像度: 2.38 Å
PDB-6w0y: Structure of KHK in complex with compound 6 (2-[(1~{R},5~{S})-3-[5-cyano-6-[(2~{S},3~{R})-2-methyl-3-oxidanyl-azetidin-1-yl]-4-(trifluoromethyl)pyridin-2-yl]-3-azabicyclo[3.1.0]hexan-6-yl]ethanoic acid) 手法: X-RAY DIFFRACTION / 解像度: 2.54 Å
PDB-6w0z: Structure of KHK in complex with compound 8 (2-[(1~{S},5~{R})-3-[2-[(2~{S})-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-yl]ethanoic acid) 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å