EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.
ジャーナル・号・ページ	Plos One, Vol. 16, Page e0245013-e0245013, Year 2021
掲載日	2020年2月16日 (構造データの登録日)
著者	Zhang, S. / Garzan, A. / Haese, N. / Bostwick, R. / Martinez-Gzegozewska, Y. / Rasmussen, L. / Streblow, D.N. / Haise, M.T. / Pathak, A.K. / Augelli-Szafran, C.E. / Wu, M.
リンク	Plos One / PubMed:33482665
手法	X線回折
解像度	1.64 - 2.34 Å
構造データ	PDB-6vuq: Crystal structure of CHIKV nsP3 macrodomain soaked with ADP-ribose 手法: X-RAY DIFFRACTION / 解像度: 1.64 Å PDB-6w0t: Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6w7h: Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6w8k: Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6w8m: Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-6w8q: Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments 手法: X-RAY DIFFRACTION / 解像度: 2.34 Å PDB-6w8y: Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6w8z: Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6w91: Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments 手法: X-RAY DIFFRACTION / 解像度: 2.21 Å
化合物	ChemComp-APR: ADENOSINE-5-DIPHOSPHORIBOSE ChemComp-HOH: WATER ChemComp-S6Y: 6-(2-methylpropyl)-2-oxidanylidene-5~{H}-pyrimidine-4-carboxylic acid ChemComp-TEV: 6-methyl-2-oxo-2,5-dihydropyrimidine-4-carboxylic acid ChemComp-TJ4: 5,6-dimethyl-2-oxo-2,3-dihydropyrimidine-4-carboxylic acid ChemComp-TJY: 2-oxo-1,2-dihydroquinazoline-4-carboxylic acid ChemComp-TJS: 2-oxo-1,2,5,6,7,8-hexahydroquinazoline-4-carboxylic acid ChemComp-TJJ: 2-oxo-2,3-dihydropyrimidine-4-carboxylic acid / 2-ヒドロキシピリミジン-4-カルボン酸 ChemComp-TJD: methyl 2-oxo-1,2-dihydroquinazoline-4-carboxylate ChemComp-TJP: methyl 2-oxo-2,5-dihydropyrimidine-4-carboxylate
由来	chikungunya virus (チクングニヤウイルス) chikungunya virus (strain 37997) (ウイルス)
キーワード	VIRAL PROTEIN / nsP3 / macrodomain / Chikungunya virus / pyrimidone fragments