タイトル | Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2') enzymes. |
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ジャーナル・号・ページ | Sci Rep, Vol. 11, Page 11614-11614, Year 2021 |
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掲載日 | 2020年2月6日 (構造データの登録日) |
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著者 | Bassenden, A.V. / Dumalo, L. / Park, J. / Blanchet, J. / Maiti, K. / Arya, D.P. / Berghuis, A.M. |
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リンク | Sci Rep / PubMed:34078922 |
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手法 | X線回折 |
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解像度 | 1.3 - 2 Å |
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構造データ | PDB-6vr2: Aminoglycoside N-2'-Acetyltransferase-Ia [AAC(2')-Ia] in complex with acetylated-tobramycin and CoA 手法: X-RAY DIFFRACTION / 解像度: 1.77 Å PDB-6vr3: Aminoglycoside N-2'-Acetyltransferase-Ia [AAC(2')-Ia] in complex with acetylated-netilmicin and CoA 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-6vta: Aminoglycoside N-2'-Acetyltransferase-Ia [AAC(2')-Ia] in complex with amikacin and acetyl-CoA 手法: X-RAY DIFFRACTION / 解像度: 1.42 Å PDB-7jzs: Aminoglycoside N-2'-Acetyltransferase-Ia [AAC(2')-Ia] in complex with CoA 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å |
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化合物 | ChemComp-R7Y: (1S,2S,3R,4S,6R)-3-{[2-(acetylamino)-6-amino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl]oxy}-4,6-diamino-2-hydroxycycloh
ChemComp-NTL: N-[(2S,3R)-2-{[(1R,2S,3S,4R,6S)-6-amino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-lyxopyranosyl]oxy}-4-(ethylamino)
ChemComp-AKN: (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S / アミカシン / 薬剤, 抗生剤*YM
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由来 | - providencia stuartii (バクテリア)
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キーワード | TRANSFERASE / Acetyltransferase / GNAT superfamily |
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