EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
ジャーナル・号・ページ	Elife, Vol. 11, Year 2022
掲載日	2019年7月12日 (構造データの登録日)
著者	Hosfield, D.J. / Weber, S. / Li, N.S. / Suavage, M. / Joiner, C.F. / Hancock, G.R. / Sullivan, E.A. / Ndukwe, E. / Han, R. / Cush, S. ...Hosfield, D.J. / Weber, S. / Li, N.S. / Suavage, M. / Joiner, C.F. / Hancock, G.R. / Sullivan, E.A. / Ndukwe, E. / Han, R. / Cush, S. / Laine, M. / Mader, S.C. / Greene, G.L. / Fanning, S.W.
リンク	Elife / PubMed:35575456
手法	X線回折
解像度	1.449 - 2.6 Å
構造データ	PDB-6psj: Bazedoxifene in Complex with Y537S Estrogen Receptor Alpha Ligand Binding Domain 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6v8t: Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with LSZ102 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6vpf: Estrogen Receptor Alpha Ligand Binding Domain in Complex with the Selective Estrogen Receptor Modulator Clomiphene 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-7kbs: Estrogen Receptor Alpha Ligand Binding Domain in Complex with Raloxifene 手法: X-RAY DIFFRACTION / 解像度: 1.834 Å PDB-7uj7: Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with RU39411 手法: X-RAY DIFFRACTION / 解像度: 1.68 Å PDB-7uj8: Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with 4-Hydroxytamoxifen 手法: X-RAY DIFFRACTION / 解像度: 2.385 Å PDB-7ujc: Raloxifene in Complex with Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutation 手法: X-RAY DIFFRACTION / 解像度: 1.78 Å PDB-7ujf: Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Methylated Lasofoxifene Derivative with Selective Estrogen Receptor Degrader Properties 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7ujm: Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Methylated Lasofoxifene Derivative That Increases Receptor Resonance Time in the Nucleus of Breast Cancer Cells 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7ujo: Estrogen Receptor Alpha Ligand Binding Domain in Complex with RU39411 手法: X-RAY DIFFRACTION / 解像度: 1.449 Å PDB-7ujw: Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with a Methylated Lasofoxifene Derivative that Possesses Selective Estrogen Receptor Degrader Activities 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-7ujy: Estrogen receptor alpha ligand binding domain Y537S mutant in complex with a methylated lasofoxifene derivative that enhances estrogen receptor alpha nuclear resonance time 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å
化合物	ChemComp-29S: Bazedoxifene / バゼドキシフェン / 薬剤YM ChemComp-HOH: WATER ChemComp-C6V: LSZ102 ChemComp-53Q: Clomifene ChemComp-RAL: RALOXIFENE / ラロキシフェン / 薬剤YM ChemComp-NYU: 11alpha-{4-[2-(dimethylamino)ethoxy]phenyl}estra-1(10),2,4-triene-3,17beta-diol / RU-39411 ChemComp-OHT: 4-HYDROXYTAMOXIFEN / cis-4-ヒドロキシタモキシフェン ChemComp-R3V: (5R,6S)-5-(4-{2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol ChemComp-RL4: (5R,6S)-5-(4-{2-[(2R)-2-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol ChemComp-QYM: (9beta,11beta,17beta)-11-{4-[2-(dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol ChemComp-MG: Unknown entry / マグネシウムジカチオン
由来	homo sapiens (ヒト)
キーワード	TRANSCRIPTION / Estrogen Receptor / Y537S / Bazedoxifene / Steroid / Hormone / Breast cancer / acquired drug resistance / hormone therapy / selective estrogen receptor degrader/downregulator / TRANSFERASE / Selective Estrogen Receptor Modulator / Antiestrogen / Alpha Helical Bundle / SERM / RU39411 / Activating Mutations / hormone receptor / tamoxifen / activating mutation / estrogen / ESTROGEN RECEPTOR ALPHA / DRUG RESISTANCE / ALP HELICAL BUNDLE