タイトル | High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. USA, Vol. 117, Page 12826-12835, Year 2020 |
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掲載日 | 2019年10月8日 (構造データの登録日) |
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著者 | Sim, M.J.W. / Lu, J. / Spencer, M. / Hopkins, F. / Tran, E. / Rosenberg, S.A. / Long, E.O. / Sun, P.D. |
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リンク | Proc. Natl. Acad. Sci. USA / PubMed:32461371 |
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手法 | X線回折 |
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解像度 | 1.88 - 3.5 Å |
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構造データ | PDB-6uli: Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-6ulk: Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6uln: Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation 手法: X-RAY DIFFRACTION / 解像度: 2.01 Å PDB-6ulr: Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation 手法: X-RAY DIFFRACTION / 解像度: 3.2 Å PDB-6uon: Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation 手法: X-RAY DIFFRACTION / 解像度: 3.5 Å |
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化合物 | |
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由来 | homo sapiens (ヒト)
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キーワード | IMMUNE SYSTEM / HLA-C Neoantigen KRAS |
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