タイトル | Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90. |
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ジャーナル・号・ページ | J. Am. Chem. Soc., Vol. 142, Page 3392-3400, Year 2020 |
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掲載日 | 2019年9月6日 (構造データの登録日) |
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著者 | Cuesta, A. / Wan, X. / Burlingame, A.L. / Taunton, J. |
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リンク | J. Am. Chem. Soc. / PubMed:32009391 |
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手法 | X線回折 |
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解像度 | 1.5 - 1.75 Å |
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構造データ | PDB-6u98: Hsp90a NTD K58R bound reversibly to sulfonyl fluoride 6 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6u99: Hsp90a NTD covalently bound to sulfonyl fluoride probe 1 at K58 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6u9a: Hsp90a NTD K58R bound reversibly to sulfonyl fluoride 5 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-6u9b: Hsp90a NTD covalently bound to sulfonyl fluoride 5 at K58 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å |
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化合物 | ChemComp-Q2D: 3-{[(3R)-3-({6-amino-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}methyl)piperidin-1-yl]methyl}benzene-1-sulfonyl fluoride
ChemComp-Q2J: 3-{[(3-{6-amino-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}propyl)amino]methyl}benzene-1-sulfinic acid
ChemComp-Q2A: 3-{[(3S)-3-({6-amino-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}methyl)piperidin-1-yl]methyl}benzene-1-sulfonyl fluoride
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由来 | - homo sapiens (ヒト)
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キーワード | CHAPERONE/INHIBITOR / inhibitor / lysine-targeted inhibitor / CHAPERONE / CHAPERONE-INHIBITOR complex |
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