EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
ジャーナル・号・ページ	J. Med. Chem., Vol. 62, Page 11232-11259, Year 2019
掲載日	2019年8月28日 (構造データの登録日)
著者	Macdonald, J.D. / Chacon Simon, S. / Han, C. / Wang, F. / Shaw, J.G. / Howes, J.E. / Sai, J. / Yuh, J.P. / Camper, D. / Alicie, B.M. ...Macdonald, J.D. / Chacon Simon, S. / Han, C. / Wang, F. / Shaw, J.G. / Howes, J.E. / Sai, J. / Yuh, J.P. / Camper, D. / Alicie, B.M. / Alvarado, J. / Nikhar, S. / Payne, W. / Aho, E.R. / Bauer, J.A. / Zhao, B. / Phan, J. / Thomas, L.R. / Rossanese, O.W. / Tansey, W.P. / Waterson, A.G. / Stauffer, S.R. / Fesik, S.W.
リンク	J. Med. Chem. / PubMed:31724864
手法	X線回折
解像度	1.2 - 1.8 Å
構造データ	PDB-6u5m: Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6u5y: Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction 手法: X-RAY DIFFRACTION / 解像度: 1.532 Å PDB-6u6w: Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-6u80: Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-6u8b: Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction 手法: X-RAY DIFFRACTION / 解像度: 1.261 Å PDB-6u8l: Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction 手法: X-RAY DIFFRACTION / 解像度: 1.57 Å PDB-6u8o: Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å
化合物	ChemComp-Q0S: 5-bromo-2-hydroxy-N-[3-(methylsulfonyl)-5-(pentafluoro-lambda~6~-sulfanyl)phenyl]benzene-1-sulfonamide ChemComp-HOH: WATER ChemComp-Q0M: 3-{[(5-bromo-3-chloro-2-hydroxyphenyl)sulfonyl]amino}-5-(1-cyanocyclobutyl)-2-hydroxy-N-methylbenzamide ChemComp-Q0Y: 5-bromo-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzene-1-sulfonamide ChemComp-Q1J: 5-bromo-N-(4-hydroxy[1,1'-biphenyl]-3-yl)-2-methoxybenzene-1-sulfonamide ChemComp-Q1M: 3-{[(5-bromo-2-methoxyphenyl)sulfonyl]amino}-5-chloro-2-hydroxybenzoic acid ChemComp-Q1P: 3-{[(5-bromo-2-hydroxyphenyl)sulfonyl]amino}-5-cyclopropyl-6-fluoro-2-hydroxybenzoic acid ChemComp-Q1S: N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]isoquinolin-1-amine ChemComp-Q1G: 5-bromo-N-[5-(1-cyanocyclobutyl)-2-hydroxyphenyl]-2-hydroxybenzene-1-sulfonamide
由来	homo sapiens (ヒト)
キーワード	TRANSCRIPTION / WDR5 / MYC / RBBP5 / structure-based design / high-throughput screening / TRANSCRIPTION/INHIBITOR / TRANSCRIPTION-INHIBITOR complex