EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t.
ジャーナル・号・ページ	Proc. Natl. Acad. Sci. USA, Vol. 118, Year 2021
掲載日	2019年10月14日 (構造データの登録日)
著者	de Vries, R.M.J.M. / Meijer, F.A. / Doveston, R.G. / Leijten-van de Gevel, I.A. / Brunsveld, L.
リンク	Proc. Natl. Acad. Sci. USA / PubMed:33536342
手法	X線回折
解像度	1.48 - 2.11 Å
構造データ	PDB-6t4g: ROR(gamma)t ligand binding domain in complex with cholesterol and allosteric ligand FM26 手法: X-RAY DIFFRACTION / 解像度: 1.93 Å PDB-6t4i: ROR(gamma)t ligand binding domain in complex with cholesterol and allosteric ligand MRL871 手法: X-RAY DIFFRACTION / 解像度: 1.84 Å PDB-6t4j: ROR(gamma)t ligand binding domain in complex with desmosterol and allosteric ligand FM26 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å PDB-6t4k: ROR(gamma)t ligand binding domain in complex with desmosterol and allosteric ligand MRL871 手法: X-RAY DIFFRACTION / 解像度: 1.89 Å PDB-6t4t: ROR(gamma)t ligand binding domain in complex with 20-alpha-hydroxycholesterol and allosteric ligand FM26 手法: X-RAY DIFFRACTION / 解像度: 1.62 Å PDB-6t4u: ROR(gamma)t ligand binding domain in complex with 20-alpha-hydroxycholesterol and allosteric ligand MRL871 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-6t4w: ROR(gamma)t ligand binding domain in complex with 20-alpha-hydroxycholesterol and allosteric ligand Glenmark 手法: X-RAY DIFFRACTION / 解像度: 1.71 Å PDB-6t4x: ROR(gamma)t ligand binding domain in complex with 25-hydroxycholesterol and allosteric ligand FM26 手法: X-RAY DIFFRACTION / 解像度: 1.48 Å PDB-6t4y: ROR(gamma)t ligand binding domain in complex with 25-hydroxycholesterol and allosteric ligand MRL871 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6t50: ROR(gamma)t ligand binding domain in complex with 25-hydroxycholesterol and allosteric ligand Glenmark 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-6tlq: ROR(gamma)t ligand binding domain in complex with cholesterol and allosteric ligand Glenmark 手法: X-RAY DIFFRACTION / 解像度: 1.761 Å PDB-6tlt: ROR(gamma)t ligand binding domain in complex with desmosterol and allosteric ligand Glenmark 手法: X-RAY DIFFRACTION / 解像度: 2.11 Å
化合物	ChemComp-CLR: CHOLESTEROL / コレステロ-ル ChemComp-L3E: 4-[(~{E})-[3-[2-chloranyl-6-(trifluoromethyl)phenyl]-5-(1~{H}-pyrrol-3-yl)-1,2-oxazol-4-yl]methylideneamino]benzoic acid ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-HOH: WATER ChemComp-4F1: 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-1H-indazol-3-yl}benzoic acid ChemComp-MHQ: desmosterol / デスモステロ-ル ChemComp-HCD: (3alpha,8alpha)-cholest-5-ene-3,20-diol / (20S)-20-ヒドロキシコレステロ-ル ChemComp-MJE: 4-[1-[2,6-bis(chloranyl)phenyl]carbonyl-5-methyl-thieno[3,2-c]pyrazol-3-yl]benzoic acid ChemComp-HC3: 25-HYDROXYCHOLESTEROL / 25-ヒドロキシコレステロ-ル
由来	homo sapiens (ヒト)
キーワード	GENE REGULATION / Nuclear Receptor / Allosteric / Inverse Agonist / Inhibitor