タイトル | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. |
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ジャーナル・号・ページ | Acs Chem. Biol., Vol. 15, Page 618-625, Year 2020 |
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掲載日 | 2019年10月1日 (構造データの登録日) |
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著者 | Bedi, R.K. / Huang, D. / Wiedmer, L. / Li, Y. / Dolbois, A. / Wojdyla, J.A. / Sharpe, M.E. / Caflisch, A. / Sledz, P. |
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リンク | Acs Chem. Biol. / PubMed:32101404 |
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手法 | X線回折 |
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解像度 | 1.1 - 2.4 Å |
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構造データ | PDB-6syz: Crystal structure of YTHDC1 with fragment 1 (DHU_DC1_141) 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-6sz1: Crystal structure of YTHDC1 with fragment 2 (DHU_DC1_140) 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-6sz2: Crystal structure of YTHDC1 with fragment 3 (DHU_DC1_149) 手法: X-RAY DIFFRACTION / 解像度: 1.52 Å PDB-6sz3: Crystal structure of YTHDC1 with fragment 4 (DHU_DC1_158) 手法: X-RAY DIFFRACTION / 解像度: 1.28 Å PDB-6sz7: Crystal structure of YTHDC1 with fragment 5 (DHU_DC1_066) 手法: X-RAY DIFFRACTION / 解像度: 2.31 Å PDB-6sz8: Crystal structure of YTHDC1 with fragment 6 (DHU_DC1_034) 手法: X-RAY DIFFRACTION / 解像度: 1.47 Å PDB-6szl: Crystal structure of YTHDC1 with fragment 7 (DHU_DC1_021) 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-6szn: Crystal structure of YTHDC1 with fragment 8 (DHU_DC1_006) 手法: X-RAY DIFFRACTION / 解像度: 1.47 Å PDB-6szr: Crystal structure of YTHDC1 with fragment 9 (DHU_DC1_107) 手法: X-RAY DIFFRACTION / 解像度: 1.64 Å PDB-6szt: Crystal structure of YTHDC1 with fragment 10 (DHU_DC1_076) 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6szx: Crystal structure of YTHDC1 with fragment 11 (DHU_DC1_128) 手法: X-RAY DIFFRACTION / 解像度: 1.17 Å PDB-6szy: Crystal structure of YTHDC1 with fragment 12 (DHU_DC1_150) 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å PDB-6t01: Crystal structure of YTHDC1 with fragment 13 (DHU_DC1_153) 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6t02: Crystal structure of YTHDC1 with fragment 15 (DHU_DC1_169) 手法: X-RAY DIFFRACTION / 解像度: 1.1 Å PDB-6t03: Crystal structure of YTHDC1 with fragment 16 (DHU_DC1_017) 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6t04: Crystal structure of YTHDC1 with fragment 17 (DHU_DC1_042) 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6t05: Crystal structure of YTHDC1 with fragment 18 (DHU_DC1_048) 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6t06: Crystal structure of YTHDC1 with fragment 19 (DHU_DC1_045) 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-6t07: Crystal structure of YTHDC1 with fragment 20 (DHU_DC1_134) 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6t08: Crystal structure of YTHDC1 with fragment 21 (DHU_DC1_131) 手法: X-RAY DIFFRACTION / 解像度: 1.41 Å PDB-6t09: Crystal structure of YTHDC1 with fragment 24 (PSI_DC1_003) 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-6t0a: Crystal structure of YTHDC1 with fragment 25 (PSI_DC1_005) 手法: X-RAY DIFFRACTION / 解像度: 2.02 Å PDB-6t0c: Crystal structure of YTHDC1 with fragment 26 (DHU_DC1_198) 手法: X-RAY DIFFRACTION / 解像度: 2.03 Å PDB-6t0d: Crystal structure of YTHDC1 with fragment 27 (DHU_DC1_256) 手法: X-RAY DIFFRACTION / 解像度: 1.43 Å PDB-6t0o: Crystal structure of YTHDC1 with fragment 14 (ACA_DC1_004) 手法: X-RAY DIFFRACTION / 解像度: 1.71 Å PDB-6t0x: Crystal structure of YTHDC1 with fragment 22 (ACA_DC1_001) 手法: X-RAY DIFFRACTION / 解像度: 1.36 Å PDB-6t0z: Crystal structure of YTHDC1 with fragment 23 (ACA_DC1_005) 手法: X-RAY DIFFRACTION / 解像度: 1.43 Å PDB-6t10: Crystal structure of YTHDC1 with fragment 28 (DHU_DC1_176) 手法: X-RAY DIFFRACTION / 解像度: 1.48 Å PDB-6t11: Crystal structure of YTHDC1 with fragment 29 (DHU_DC1_218) 手法: X-RAY DIFFRACTION / 解像度: 1.49 Å PDB-6t12: Crystal structure of YTHDC1 with fragment 30 (DHU_DC1_220) 手法: X-RAY DIFFRACTION / 解像度: 1.46 Å |
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化合物 | ChemComp-M1E: ~{N}-methylthieno[3,2-d]pyrimidin-4-amine
ChemComp-M1H: ~{N}-methyl-5,6,7,8-tetrahydroquinolin-4-amine
ChemComp-M1Q: 5,6,7,8-tetrahydro-4~{a}~{H}-quinazoline-2,4-dione
ChemComp-M1Z: 6-pyrrolidin-1-yl-5~{H}-pyrimidine-2,4-dione
ChemComp-M3Z: 6-[[methyl-(phenylmethyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione
ChemComp-M4Q: 6-[[methyl(thiophen-3-ylmethyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione
ChemComp-M4K: 6-[[cyclopropyl-(phenylmethyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione
ChemComp-M5N: 4-propan-2-yl-5,6,7,8-tetrahydro-4~{a}~{H}-quinazolin-2-one
ChemComp-M4B: 6-methyl-5-nitro-4-phenyl-1~{H}-pyrimidin-2-one
ChemComp-M45: ~{N}-[(2~{S})-pyrrolidin-2-yl]-1~{H}-1,2,4-triazol-5-amine
ChemComp-M5B: ~{N}-(1~{H}-imidazol-2-yl)thiophene-2-sulfonamide
ChemComp-M4E: ~{N}-methyl-2~{H}-indazole-3-carboxamide
ChemComp-M6N: 2-methyl-3~{H}-pyrido[3,4-d]pyrimidin-4-one
ChemComp-M6W: (3~{S})-~{N}-methylpyrrolidine-3-carboxamide
ChemComp-M75: ~{N}-cyclopropyl-1~{H}-imidazole-4-sulfonamide
ChemComp-M6Z: 5-iodanyl-~{N}-methyl-1~{H}-indazole-3-carboxamide
ChemComp-M78: ~{N},2,3-trimethyl-1~{H}-indole-5-carboxamide
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由来 | - homo sapiens (ヒト)
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キーワード | RNA BINDING PROTEIN / Fragment / Complex / YTHDC1 / Epitranscriptomic |
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