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-Structure paper
タイトル | Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC). |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 62, Page 11004-11018, Year 2019 |
掲載日 | 2019年8月19日 (構造データの登録日) |
![]() | Ward, R.A. / Anderton, M.J. / Bethel, P. / Breed, J. / Cook, C. / Davies, E.J. / Dobson, A. / Dong, Z. / Fairley, G. / Farrington, P. ...Ward, R.A. / Anderton, M.J. / Bethel, P. / Breed, J. / Cook, C. / Davies, E.J. / Dobson, A. / Dong, Z. / Fairley, G. / Farrington, P. / Feron, L. / Flemington, V. / Gibbons, F.D. / Graham, M.A. / Greenwood, R. / Hanson, L. / Hopcroft, P. / Howells, R. / Hudson, J. / James, M. / Jones, C.D. / Jones, C.R. / Li, Y. / Lamont, S. / Lewis, R. / Lindsay, N. / McCabe, J. / McGuire, T. / Rawlins, P. / Roberts, K. / Sandin, L. / Simpson, I. / Swallow, S. / Tang, J. / Tomkinson, G. / Tonge, M. / Wang, Z. / Zhai, B. |
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手法 | X線回折 |
解像度 | 1.33 Å |
構造データ | ![]() PDB-6slg: |
化合物 | ![]() ChemComp-LHZ: ![]() ChemComp-SO4: ![]() ChemComp-EDO: ![]() ChemComp-HOH: |
由来 |
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![]() | TRANSFERASE / ERK2 / KINASE / INHIBITOR / ONCOLOGY |