EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors.
ジャーナル・号・ページ	J. Am. Chem. Soc., Vol. 142, Page 13021-13029, Year 2020
掲載日	2019年5月14日 (構造データの登録日)
著者	Armstrong, Z. / Kuo, C.L. / Lahav, D. / Liu, B. / Johnson, R. / Beenakker, T.J.M. / de Boer, C. / Wong, C.S. / van Rijssel, E.R. / Debets, M.F. ...Armstrong, Z. / Kuo, C.L. / Lahav, D. / Liu, B. / Johnson, R. / Beenakker, T.J.M. / de Boer, C. / Wong, C.S. / van Rijssel, E.R. / Debets, M.F. / Florea, B.I. / Hissink, C. / Boot, R.G. / Geurink, P.P. / Ovaa, H. / van der Stelt, M. / van der Marel, G.M. / Codee, J.D.C. / Aerts, J.M.F.G. / Wu, L. / Overkleeft, H.S. / Davies, G.J.
リンク	J. Am. Chem. Soc. / PubMed:32605368
手法	X線回折
解像度	1.53 - 2.15 Å
構造データ	PDB-6rpc: GOLGI ALPHA-MANNOSIDASE II 手法: X-RAY DIFFRACTION / 解像度: 1.69 Å PDB-6rqz: GOLGI ALPHA-MANNOSIDASE II complex with Manno-epi-cyclophellitol aziridine 手法: X-RAY DIFFRACTION / 解像度: 1.53 Å PDB-6rrh: GOLGI ALPHA-MANNOSIDASE II 手法: X-RAY DIFFRACTION / 解像度: 2.07 Å PDB-6rrj: GOLGI ALPHA-MANNOSIDASE II in complex with 5-(Adamantan-1yl-methoxy)-pentyl 2,5-dideoxy-2,5-imino-D-talo-hexonamide 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6rrn: GOLGI ALPHA-MANNOSIDASE II in complex with pentyl 2,5-dideoxy-2,5-imino-D-talo-hexonamide 手法: X-RAY DIFFRACTION / 解像度: 1.59 Å PDB-6rru: GOLGI ALPHA-MANNOSIDASE II in complex with (5R,6R,7S,8S)-5,6,7,8-tetrahydro-5-(hydroxymethyl)-3-(3-phenylpropyl)imidazo[1,2-a]pyridine-6,7,8-triol 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6rrw: GOLGI ALPHA-MANNOSIDASE II in complex with (2R,3R,4R,5S)-1-(5-{[4-(3,4-Dihydro-2H-1,5-benzodioxepin-7-yl)benzyl]oxy}pentyl)-2-(hydroxymethyl)-3,4,5-piperidinetriol 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-6rrx: GOLGI ALPHA-MANNOSIDASE II in complex with (2S,3R)-2-(Hydroxymethyl)-3-piperidinol 手法: X-RAY DIFFRACTION / 解像度: 1.84 Å PDB-6rry: GOLGI ALPHA-MANNOSIDASE II in complex with (2S,3R)-2-(Hydroxymethyl)-1,2,3,6-tetrahydro-3-pyridinol 手法: X-RAY DIFFRACTION / 解像度: 1.86 Å PDB-6rs0: GOLGI ALPHA-MANNOSIDASE II in complex with (2S,3S,4R,5R)-1-(2-(Benzyloxy)ethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å
化合物	ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-SIN: SUCCINIC ACID / コハク酸 ChemComp-ZN: Unknown entry ChemComp-HOH: WATER ChemComp-KGH: (1~{R},2~{S},3~{R},4~{R},5~{S},6~{R})-5-azanyl-6-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol ChemComp-KFE: (2~{S},3~{R},4~{S},5~{R})-~{N}-[5-(1-adamantylmethoxy)pentyl]-5-(hydroxymethyl)-3,4-bis(oxidanyl)pyrrolidine-2-carboxamide ChemComp-KFT: (2~{S},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)-~{N}-pentyl-pyrrolidine-2-carboxamide / N-ペンチル-3β,4β-ジヒドロキシ-5β-(ヒドロキシメチル)ピロリジン-2α-カルボアミド ChemComp-KG8: (5~{R},6~{R},7~{S},8~{S})-5-(hydroxymethyl)-2-(3-phenylpropyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-6,7,8-triol / 2-ヒドロシンナミル-5α-(ヒドロキシメチル)-5,6,7,8-テトラヒドロイミダゾ[1,2-a]ピリジン-6β,7(以下略) ChemComp-KG5: (2~{R},3~{R},4~{R},5~{S})-1-[5-[[4-(3,4-dihydro-2~{H}-1,5-benzodioxepin-7-yl)phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol ChemComp-KFW: (2~{S},3~{R})-2-(hydroxymethyl)piperidin-3-ol ChemComp-KGE: (2~{S},3~{R})-2-(hydroxymethyl)-1,2,3,6-tetrahydropyridin-3-ol ChemComp-KGB: (2~{S},3~{S},4~{R})-2-(hydroxymethyl)-1-(2-phenylmethoxyethyl)piperidine-3,4,5-triol
由来	drosophila melanogaster (キイロショウジョウバエ)
キーワード	HYDROLASE / Mannosidase / Glycoside Hydrolase