タイトル | Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights. |
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ジャーナル・号・ページ | Int J Mol Sci, Vol. 21, Year 2020 |
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掲載日 | 2019年5月9日 (構造データの登録日) |
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著者 | Rieux, C. / Goffinont, S. / Coste, F. / Tber, Z. / Cros, J. / Roy, V. / Guerin, M. / Gaudon, V. / Bourg, S. / Biela, A. ...Rieux, C. / Goffinont, S. / Coste, F. / Tber, Z. / Cros, J. / Roy, V. / Guerin, M. / Gaudon, V. / Bourg, S. / Biela, A. / Aucagne, V. / Agrofoglio, L. / Garnier, N. / Castaing, B. |
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リンク | Int J Mol Sci / PubMed:32192183 |
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手法 | X線回折 |
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解像度 | 1.76 - 2.25 Å |
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構造データ | PDB-6rnm: Crystal structure of a complex between the LlFpg protein, a THF-DNA and an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.76 Å PDB-6rno: Crystal structure of a complex between the LlFpg protein, a THF-DNA and an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-6rnr: The crystal structure of a complex between the LlFpg protein, a THF-DNA and an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.003 Å PDB-6ro2: The crystal structure of a complex between the LlFpg protein, a THF-DNA and an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.821 Å PDB-6rok: The crystal structure of a complex between the LlFpg protein, a THF-DNA and an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6rp0: The crystal structure of a complex between the LlFpg protein, a THF-DNA and an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-6rp7: The crystal structure of a complex between the LlFpg protein, a THF-DNA and an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å |
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化合物 | ChemComp-KBQ: 2-sulfanylidene-1,7-dihydropyrrolo[2,3-d]pyrimidin-4-one
ChemComp-KBN: 2-(trifluoromethyl)-9~{H}-purine-6-thiol
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由来 | - lactococcus lactis subsp. cremoris (乳酸菌)
- synthetic construct (人工物)
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キーワード | HYDROLASE / DNA glycosylase complex / inhibitor |
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