タイトル | Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. |
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ジャーナル・号・ページ | J. Struct. Biol., Vol. 208, Page 165-173, Year 2019 |
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掲載日 | 2019年3月26日 (構造データの登録日) |
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著者 | Loconte, V. / Menozzi, I. / Ferrari, A. / Folli, C. / Imbimbo, B.P. / Zanotti, G. / Berni, R. |
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リンク | J. Struct. Biol. / PubMed:31473362 |
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手法 | X線回折 |
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解像度 | 1.3 - 1.467 Å |
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構造データ | PDB-6r66: Crystal structure of transthyretin in complex with CHF5075, a flurbiprofen analogue 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-6r67: Crystal structure of transthyretin in complex with CHF5075, a flurbiprofen analogue 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-6r68: Crystal structure of transthyretin in complex with CHF4795, a flurbiprofen analogue 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-6r6i: Crystal structure of transthyretin mutant A25T in complex with CHF5074, a flurbiprofen analogue 手法: X-RAY DIFFRACTION / 解像度: 1.467 Å |
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化合物 | ChemComp-JTN: 1-[4-[3,5-bis(chloranyl)phenyl]-3-fluoranyl-phenyl]cyclopropane-1-carboxylic acid
ChemComp-JTE: (2~{R})-2-[4-(3,5-dimethylphenyl)-3-fluoranyl-phenyl]propanoic acid
ChemComp-JTK: (2~{R})-2-[4-[3,5-bis(chloranyl)phenyl]-3-fluoranyl-phenyl]propanoic acid
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由来 | homo sapiens (ヒト)
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キーワード | TRANSPORT PROTEIN / Amyloidosis / tetramer / binding protein |
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