EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity.
ジャーナル・号・ページ	J. Med. Chem., Vol. 62, Page 6913-6924, Year 2019
掲載日	2019年3月7日 (構造データの登録日)
著者	Szlavik, Z. / Ondi, L. / Csekei, M. / Paczal, A. / Szabo, Z.B. / Radics, G. / Murray, J. / Davidson, J. / Chen, I. / Davis, B. ...Szlavik, Z. / Ondi, L. / Csekei, M. / Paczal, A. / Szabo, Z.B. / Radics, G. / Murray, J. / Davidson, J. / Chen, I. / Davis, B. / Hubbard, R.E. / Pedder, C. / Dokurno, P. / Surgenor, A. / Smith, J. / Robertson, A. / LeToumelin-Braizat, G. / Cauquil, N. / Zarka, M. / Demarles, D. / Perron-Sierra, F. / Claperon, A. / Colland, F. / Geneste, O. / Kotschy, A.
リンク	J. Med. Chem. / PubMed:31339316
手法	X線回折
解像度	1.7 - 2.5 Å
構造データ	PDB-6qxj: Structure of MBP-Mcl-1 in complex with compound 6a 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-6qyk: Structure of MBP-Mcl-1 in complex with compound 7a 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-6qyl: Structure of MBP-Mcl-1 in complex with compound 8a 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6qyn: Structure of MBP-Mcl-1 in complex with compound 10d 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-6qyo: Structure of MBP-Mcl-1 in complex with compound 18a 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6qyp: Structure of Mcl-1 in complex with compound 13 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6qz5: Structure of Mcl-1 in complex with compound 8a 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-6qz6: Structure of Mcl-1 in complex with compound 8b 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6qz7: Structure of MBP-Mcl-1 in complex with compound 8b 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6qz8: Structure of Mcl-1 in complex with compound 10d 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-6qzb: Structure of Mcl-1 in complex with compound 8d 手法: X-RAY DIFFRACTION / 解像度: 2 Å
化合物	ChemComp-JKQ: (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-5-yl)thieno[2,3-d]pyrimidin-4-yl]amino]propanoic acid ChemComp-NA: Unknown entry / ナトリウムカチオン ChemComp-HOH: WATER ChemComp-JLB: (2~{R})-2-[6-ethyl-5-(1~{H}-indol-5-yl)thieno[2,3-d]pyrimidin-4-yl]oxypropanoic acid ChemComp-JLE: (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-4-yl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid ChemComp-JL8: (2~{R})-2-[5-(3-chloranyl-2-methyl-4-oxidanyl-phenyl)-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic acid ChemComp-JLH: (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic acid ChemComp-JL5: (2~{R})-2-[5-[3-chloranyl-2-methyl-5-(4-methylpiperazin-1-yl)-4-oxidanyl-phenyl]-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic acid ChemComp-JLK: (2~{R})-2-[[6-ethyl-5-(2-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid
由来	escherichia coli o157:h7 (大腸菌) homo sapiens (ヒト) escherichia coli (大腸菌)
キーワード	APOPTOSIS / Apoptosis-inhibitor complex / Mcl1 / Small molecule inhibitor / MBP