タイトル | Molecular Basis of Class A beta-Lactamase Inhibition by Relebactam. |
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ジャーナル・号・ページ | Antimicrob. Agents Chemother., Vol. 63, Year 2019 |
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掲載日 | 2019年3月5日 (構造データの登録日) |
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著者 | Tooke, C.L. / Hinchliffe, P. / Lang, P.A. / Mulholland, A.J. / Brem, J. / Schofield, C.J. / Spencer, J. |
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リンク | Antimicrob. Agents Chemother. / PubMed:31383664 |
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手法 | X線回折 |
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解像度 | 1.04 - 1.78 Å |
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構造データ | PDB-6qw7: Crystal structure of L2 complexed with relebactam (16 hour soak) 手法: X-RAY DIFFRACTION / 解像度: 1.78 Å PDB-6qw8: Crystal structure of CTX-M-15 complexed with relebactam (16 hour soak) 手法: X-RAY DIFFRACTION / 解像度: 1.1 Å PDB-6qw9: Crystal structure of KPC-2 complexed with relebactam (16 hour soak) 手法: X-RAY DIFFRACTION / 解像度: 1.04 Å PDB-6qwa: Crystal structure of KPC-3 complexed with relebactam (16 hour soak) 手法: X-RAY DIFFRACTION / 解像度: 1.06 Å PDB-6qwb: Crystal structure of KPC-4 complexed with relebactam (16 hour soak) 手法: X-RAY DIFFRACTION / 解像度: 1.04 Å PDB-6qwc: Crystal structure of KPC-4 complexed with relebactam (1 hour soak) 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-6qwd: Crystal structure of KPC-3 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-6qwe: Crystal structure of KPC-4 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å |
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化合物 | ChemComp-MK7: (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide
ChemComp-JJT: (2~{S})-5-azanylidene-2-(piperidin-4-ylcarbamoyl)piperidine-1-carboxylic acid
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由来 | - stenotrophomonas maltophilia (バクテリア)
- klebsiella pneumoniae (肺炎桿菌)
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キーワード | ANTIMICROBIAL PROTEIN / inhibitor / relebactam / diazabicyclooctane / antibiotic resistance. / antibiotic resistance / serine beta-lactamase |
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