タイトル Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). ジャーナル・号・ページ J. Med. Chem. , Vol. 62, Page 5541-5546, Year 2019掲載日 2019年1月10日 (構造データの登録日) 著者Wolle, P. / Engel, J. / Smith, S. / Goebel, L. / Hennes, E. / Lategahn, J. / Rauh, D. リンク J. Med. Chem. / PubMed:31083997手法 X線回折 解像度 2.1 - 2.7 Å 構造データ PDB-6qfl : 構造ビューア Structure of the mitogen activated kinase kinase 7 active conformation手法 : X-RAY DIFFRACTION / 解像度 : 2.2 Å
PDB-6qfr : 構造ビューア Structure of the mitogen activated kinase kinase 7 dfg-out conformation手法 : X-RAY DIFFRACTION / 解像度 : 2.3 Å
PDB-6qft : 構造ビューア Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidin 1b 手法 : X-RAY DIFFRACTION / 解像度 : 2.7 Å
PDB-6qg4 : 構造ビューア Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine inhibitor 1h 手法 : X-RAY DIFFRACTION / 解像度 : 2.3 Å
PDB-6qg7 : 構造ビューア Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine 1k 手法 : X-RAY DIFFRACTION / 解像度 : 2.1 Å
PDB-6qho : 構造ビューア Dual specificity mitogen-activated protein kinase kinase 7 in complex with pyrazolopyrimidine 1a手法 : X-RAY DIFFRACTION / 解像度 : 2.7 Å
PDB-6qhr : 構造ビューア Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine 1m 手法 : X-RAY DIFFRACTION / 解像度 : 2.52 Å
化合物 ChemComp-J0B : 構造ビューア 1-[(3~{R})-3-(4-azanyl-3-iodanyl-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]propan-1-one
ChemComp-J0E : 構造ビューア 1-[(3~{R})-3-[4-azanyl-3-(4-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one
ChemComp-6HL : 構造ビューア (R)-1-(3-(4-amino-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
ChemComp-J3H : 構造ビューア 1-[(3~{R})-3-(4-azanylpyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]propan-1-one
ChemComp-J3N : 構造ビューア 1-[(3~{R})-3-[4-azanyl-3-(1~{H}-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one
由来 homo sapiens (ヒト) キーワード TRANSFERASE / Protein Kinase / Kinase / MKK7