タイトル | Nucleoside Tetra- and Pentaphosphates Prepared Using a Tetraphosphorylation Reagent Are Potent Inhibitors of Ribonuclease A. |
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ジャーナル・号・ページ | J. Am. Chem. Soc., Vol. 141, Page 18400-18404, Year 2019 |
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掲載日 | 2019年7月21日 (構造データの登録日) |
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著者 | Shepard, S.M. / Windsor, I.W. / Raines, R.T. / Cummins, C.C. |
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リンク | J. Am. Chem. Soc. / PubMed:31651164 |
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手法 | X線回折 |
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解像度 | 1.49 - 1.65 Å |
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構造データ | PDB-6pvu: RNase A in complex with hexametaphosphate 手法: X-RAY DIFFRACTION / 解像度: 1.49 Å PDB-6pvv: RNase A in complex with p5A 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-6pvw: RNase A in complex with cp4pA 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6pvx: RNase A in complex with p5U 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å |
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化合物 | ChemComp-P0S: 2,4,6,8,10,12-hexahydroxy-2lambda~5~,4lambda~5~,6lambda~5~,8lambda~5~,10lambda~5~,12lambda~5~-cyclohexaphosphoxane-2,4,6,8,10,12-hexone
ChemComp-OZV: 5'-O-[(R)-hydroxy{[(4R,8S)-4,6,8-trihydroxy-2,4,6,8-tetraoxo-1,3,5,7,2lambda~5~,4lambda~5~,6lambda~5~,8lambda~5~-tetroxatetraphosphocan-2-yl]oxy}phosphoryl]adenosine
ChemComp-P0J: 2,4,6,8-tetrahydroxy-1,3,5,7,2lambda~5~,4lambda~5~,6lambda~5~,8lambda~5~-tetroxatetraphosphocane-2,4,6,8-tetrone / 2,4,6,8-テトラヒドロキシ-1,3,5,7,2,4,6,8-テトロキサテトラホスホカン-2,4,6,8-テトラオン
ChemComp-U5F: 5'-O-[(R)-hydroxy{[(S)-hydroxy{[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]oxy}phosphoryl]uridine
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由来 | ![](img/tx_mammal.gif) bos taurus (ウシ)
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キーワード | LYASE / RNase A / nucleotide / poly-phosphate / metaphosphate |
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