タイトル | The molecular basis underpinning the potency and specificity of MAIT cell antigens. |
---|
ジャーナル・号・ページ | Nat. Immunol., Vol. 21, Page 400-411, Year 2020 |
---|
掲載日 | 2019年7月18日 (構造データの登録日) |
---|
著者 | Awad, W. / Ler, G.J.M. / Xu, W. / Keller, A.N. / Mak, J.Y.W. / Lim, X.Y. / Liu, L. / Eckle, S.B.G. / Le Nours, J. / McCluskey, J. ...Awad, W. / Ler, G.J.M. / Xu, W. / Keller, A.N. / Mak, J.Y.W. / Lim, X.Y. / Liu, L. / Eckle, S.B.G. / Le Nours, J. / McCluskey, J. / Corbett, A.J. / Fairlie, D.P. / Rossjohn, J. |
---|
リンク | Nat. Immunol. / PubMed:32123373 |
---|
手法 | X線回折 |
---|
解像度 | 1.8 - 2.08 Å |
---|
構造データ | PDB-6puc: Structure of human MAIT A-F7 TCR in complex with human MR1-5-OP-RU 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6pud: Structure of human MAIT A-F7 TCR in complex with human MR1-5'OH-Pentyl-5-OP-U 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6pue: Structure of human MAIT A-F7 TCR in complex with human MR1-4'D-5-OP-RU 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6puf: Structure of human MAIT A-F7 TCR in complex with human MR1-5'D-5-OP-RU 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-6pug: Structure of human MAIT A-F7 TCR in complex with human MR1-2`OH-Ethyl-5-OP-U 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6puh: Structure of human MAIT A-F7 TCR in complex with human MR1-Ribityl-less 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-6pui: Structure of human MAIT A-F7 TCR in complex with human MR1-4'OH-Butyl-5-OP-U 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å PDB-6puj: Structure of human MAIT A-F7 TCR in complex with human MR1-3`OH-Propyl-5-OP-U 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-6puk: Structure of human MAIT A-F7 TCR in complex with human MR1-JYM72 手法: X-RAY DIFFRACTION / 解像度: 2.08 Å PDB-6pul: Structure of human MAIT A-F7 TCR in complex with human MR1 3'D-5-OP-RU 手法: X-RAY DIFFRACTION / 解像度: 1.84 Å PDB-6pum: Structure of human MAIT A-F7 TCR in complex with human MR1-2'D-5-OP-RU 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å |
---|
化合物 | ChemComp-OYD: 6-[(5-hydroxypentyl)amino]-5-[(E)-propylideneamino]pyrimidine-2,4(1H,3H)-dione
ChemComp-Q7J: 1,4-dideoxy-1-({2,6-dioxo-5-[(E)-(2-oxopropylidene)amino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-erythro-pentitol
ChemComp-2LJ: 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol
ChemComp-OZD: 6-[(2-hydroxyethyl)amino]-5-[(E)-(2-oxopropylidene)amino]pyrimidine-2,4(1H,3H)-dione
ChemComp-OYG: 6-methyl-5-[(1E)-3-oxobut-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione
ChemComp-Q7P: 6-[(4-hydroxybutyl)amino]-5-[(E)-(2-oxopropylidene)amino]pyrimidine-2,4(1H,3H)-dione
ChemComp-Q7S: 6-[(3-hydroxypropyl)amino]-5-[(E)-(2-oxopropylidene)amino]pyrimidine-2,4(1H,3H)-dione
ChemComp-OYV: 1,2-dideoxy-1-{2,6-dioxo-5-[(1E)-3-oxobut-1-en-1-yl]-1,2,3,6-tetrahydropyrimidin-4-yl}-D-ribo-hexitol
ChemComp-Q81: 1,3-dideoxy-1-({2,6-dioxo-5-[(E)-(2-oxopropylidene)amino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-erythro-pentitol
ChemComp-Q84: 1,2-dideoxy-1-({2,6-dioxo-5-[(E)-(2-oxopropylidene)amino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-erythro-pentitol
|
---|
由来 | - homo sapiens (ヒト)
|
---|
キーワード | IMMUNE SYSTEM / MAIT / MR1 / Metablite presentation |
---|