タイトル | Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B. |
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ジャーナル・号・ページ | J. Am. Chem. Soc., Vol. 141, Page 12634-12647, Year 2019 |
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掲載日 | 2019年4月15日 (構造データの登録日) |
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著者 | Cui, D.S. / Lipchock, J.M. / Brookner, D. / Loria, J.P. |
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リンク | J. Am. Chem. Soc. / PubMed:31339043 |
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手法 | X線回折 |
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解像度 | 2.06 - 2.34 Å |
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構造データ | PDB-6ol4: Protein Tyrosine Phosphatase 1B (1-301), F182A mutant, apo state 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-6olq: Protein Tyrosine Phosphatase 1B (1-301), P188A mutant, apo state 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6olv: Protein Tyrosine Phosphatase 1B (1-301), P185A mutant, apo state 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6omy: Protein Tyrosine Phosphatase 1B (1-301), P180A mutant, apo state 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6pfw: Protein Tyrosine Phosphatase 1B (1-301), T177A mutant, apo state 手法: X-RAY DIFFRACTION / 解像度: 2.34 Å PDB-6pg0: Protein Tyrosine Phosphatase 1B (1-301), P188A mutant, vanadate bound state 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6pgt: Protein Tyrosine Phosphatase 1B (1-301), T177A mutant, vanadate bound state 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6pha: Protein Tyrosine Phosphatase 1B (1-301), F182A mutant, vanadate bound state 手法: X-RAY DIFFRACTION / 解像度: 2.299 Å PDB-6phs: Protein Tyrosine Phosphatase 1B (1-301), P185A mutant, vanadate bound state 手法: X-RAY DIFFRACTION / 解像度: 2.129 Å PDB-6pm8: Protein Tyrosine Phosphatase 1B (1-301), P180A mutant, vanadate bound state 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å |
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化合物 | |
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由来 | - homo sapiens (ヒト)
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キーワード | HYDROLASE / PTP1B / PTP / multiconformer / signaling protein |
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