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-Structure paper
タイトル | Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active ROR gamma t Inverse Agonists. |
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ジャーナル・号・ページ | Acs Med. Chem. Lett., Vol. 10, Page 367-373, Year 2019 |
掲載日 | 2019年2月7日 (構造データの登録日) |
![]() | Duan, J.J. / Lu, Z. / Jiang, B. / Stachura, S. / Weigelt, C.A. / Sack, J.S. / Khan, J. / Ruzanov, M. / Galella, M.A. / Wu, D.R. ...Duan, J.J. / Lu, Z. / Jiang, B. / Stachura, S. / Weigelt, C.A. / Sack, J.S. / Khan, J. / Ruzanov, M. / Galella, M.A. / Wu, D.R. / Yarde, M. / Shen, D.R. / Shuster, D.J. / Borowski, V. / Xie, J.H. / Zhang, L. / Vanteru, S. / Gupta, A.K. / Mathur, A. / Zhao, Q. / Foster, W. / Salter-Cid, L.M. / Carter, P.H. / Dhar, T.G.M. |
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手法 | X線回折 |
解像度 | 2.27 - 2.29 Å |
構造データ | ![]() PDB-6nx1: ![]() PDB-6o98: |
化合物 | ![]() ChemComp-L7D: ![]() ChemComp-HOH: ![]() ChemComp-L8A: |
由来 |
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![]() | TRANSFERASE / MULTIPLE BINDING MODES / XENOBIOTIC / PROMISCUOUS / NUCLEAR HORMONE RECEPTOR / PXR / RORgT / TRANSCRIPTION/INHIBITOR / ligand-binding domain / inverse agonist / TRANSCRIPTION-INHIBITOR complex |