EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.
ジャーナル・号・ページ	J. Med. Chem., Vol. 62, Page 1443-1454, Year 2019
掲載日	2018年8月21日 (構造データの登録日)
著者	Gu, C. / Stashko, M.A. / Puhl-Rubio, A.C. / Chakraborty, M. / Chakraborty, A. / Frye, S.V. / Pearce, K.H. / Wang, X. / Shears, S.B. / Wang, H.
リンク	J. Med. Chem. / PubMed:30624931
手法	X線回折
解像度	1.75 - 2 Å
構造データ	PDB-6m88: Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with myricetin 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6m89: Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with quercetin 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6m8a: Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with luteolin 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-6m8b: Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with kaempferol 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6m8c: Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with isorhamnetin 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6m8d: Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with diosmetin 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-6m8e: Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with rhamnetin 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å
化合物	ChemComp-MYC: 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE / ミリセチン ChemComp-HOH: WATER ChemComp-QUE: 3,5,7,3',4'-PENTAHYDROXYFLAVONE / クエルセチン ChemComp-LU2: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one / ルテオリン ChemComp-KMP: 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE / ケンペロ-ル ChemComp-IRH: isorhamnetin / イソラムネチン ChemComp-J8D: 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one / ジオスメチン / アゴニストYM ChemComp-J8G*: 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-1-benzopyran-4-one / ラムネチン
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE/TRANSFERASE Inhibitor / kinase / inositol / inositol polyphosphate / TRANSFERASE / myricetin / flavonoid / inhibitor / natural product / TRANSFERASE-TRANSFERASE Inhibitor complex / quercetin / luteolin / kaempferol / isorhamnetin / diosmetin / rhamnetin