タイトル | Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. |
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ジャーナル・号・ページ | Chemmedchem, Vol. 14, Page 673-685, Year 2019 |
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掲載日 | 2018年9月11日 (構造データの登録日) |
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著者 | Van Lam van, T. / Ivanova, T. / Hardes, K. / Heindl, M.R. / Morty, R.E. / Bottcher-Friebertshauser, E. / Lindberg, I. / Than, M.E. / Dahms, S.O. / Steinmetzer, T. |
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リンク | Chemmedchem / PubMed:30680958 |
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手法 | X線回折 |
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解像度 | 1.9 - 2.1 Å |
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構造データ | PDB-6hlb: X-ray structure of furin in complex with the cyclic peptide c[succinyl-Phe-2-Nal-(Arg)4-Lys]-Arg-4-Amba 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-6hld: X-ray structure of furin in complex with the cyclic peptide c[succinyl-Phe-2-Nal-(Arg)3-Lys]-Lys-4-Amba 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6hle: X-ray structure of furin in complex with the P6-P2-cyclized peptide H-Lys-Arg-Arg-Tle-Lys-4-Amba 手法: X-RAY DIFFRACTION / 解像度: 1.994 Å PDB-6hza: X-ray structure of furin in complex with the cyclic peptide c[glutaryl-Arg-Arg-Lys]-Arg-4-Amba 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6hzb: X-ray structure of furin in complex with the cyclic inhibitor c[glutaryl-Arg-Arg-Lys]-Lys-4-Amba 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6hzc: X-ray structure of furin in complex with the cyclic inhibitor c[glutaryl-BVK-Lys-Arg-Arg-Tle-Lys]-4-Amba 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6hzd: X-ray structure of furin in complex with the cyclic inhibitor c[glutaryl-Arg-Arg-Arg-Lys]-Arg-4-Amba 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å |
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化合物 | ChemComp-GEB: 3-[4-(3-oxidanylidenepropyl)piperazin-1-yl]propanal
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由来 | - homo sapiens (ヒト)
- synthetic construct (人工物)
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キーワード | HYDROLASE / protease proprotein convertase inhibitor complex cyclic peptide / protease / proprotein convertase / inhibitor complex / cyclic peptide / inhibitor / complex cyclic peptide |
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