タイトル | Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. |
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ジャーナル・号・ページ | Cell Chem Biol, Vol. 26, Page 121-130.e5, Year 2019 |
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掲載日 | 2018年6月19日 (構造データの登録日) |
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著者 | Wood, D.J. / Korolchuk, S. / Tatum, N.J. / Wang, L.Z. / Endicott, J.A. / Noble, M.E.M. / Martin, M.P. |
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リンク | Cell Chem Biol / PubMed:30472117 |
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手法 | X線回折 |
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解像度 | 1.3 - 2.75 Å |
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構造データ | PDB-6gu2: CDK1/CyclinB/Cks2 in complex with Flavopiridol 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-6gu3: CDK1/CyclinB/Cks2 in complex with AZD5438 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-6gu4: CDK1/CyclinB/Cks2 in complex with CGP74514A 手法: X-RAY DIFFRACTION / 解像度: 2.73 Å PDB-6gu6: CDK1/Cks2 in complex with Dinaciclib 手法: X-RAY DIFFRACTION / 解像度: 2.33 Å PDB-6gu7: CDK1/Cks2 in complex with AZD5438 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-6gub: CDK2/CyclinA in complex with Flavopiridol 手法: X-RAY DIFFRACTION / 解像度: 2.52 Å PDB-6guc: CDK2/CyclinA in complex with SU9516 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-6gue: CDK2/CyclinA in complex with AZD5438 手法: X-RAY DIFFRACTION / 解像度: 1.99 Å PDB-6guf: CDK2/CyclinA in complex with CGP74514A 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-6guh: CDK2 in complex with AZD5438 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6guk: CDK2 in complex with CGP74514A 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å |
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化合物 | ChemComp-F9Z: 2-(2-chlorophenyl)-8-[(3~{R},4~{R})-1-methyl-3-oxidanyl-piperidin-4-yl]-5,7-bis(oxidanyl)chromen-4-one
ChemComp-FB8: 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine / AZD-5438
ChemComp-FC8: ~{N}2-[(1~{R},2~{S})-2-azanylcyclohexyl]-~{N}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamine
ChemComp-1QK: 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium
ChemComp-23D: N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE
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由来 | - homo sapiens (ヒト)
- bos taurus (ウシ)
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キーワード | CELL CYCLE / CDK1 / CYCLINB1 / CKS2 / INHIBITOR / CDK2 / CYCLINA |
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