タイトル | Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding. |
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ジャーナル・号・ページ | Febs Lett., Vol. 594, Page 933-943, Year 2020 |
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掲載日 | 2018年3月23日 (構造データの登録日) |
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著者 | Stach, L. / Morgan, R.M. / Makhlouf, L. / Douangamath, A. / von Delft, F. / Zhang, X. / Freemont, P.S. |
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リンク | Febs Lett. / PubMed:31701538 |
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手法 | X線回折 |
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解像度 | 1.903 - 2.678 Å |
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構造データ | PDB-6g2v: Crystal structure of the p97 D2 domain in a helical split-washer conformation 手法: X-RAY DIFFRACTION / 解像度: 1.903 Å PDB-6g2w: Crystal structure of the p97 D2 domain in a helical split-washer conformation 手法: X-RAY DIFFRACTION / 解像度: 2.678 Å PDB-6g2x: Crystal structure of the p97 D2 domain in a helical split-washer conformation 手法: X-RAY DIFFRACTION / 解像度: 2.078 Å PDB-6g2y: Crystal structure of the p97 D2 domain in a helical split-washer conformation 手法: X-RAY DIFFRACTION / 解像度: 2.153 Å PDB-6g2z: Crystal structure of the p97 D2 domain in a helical split-washer conformation 手法: X-RAY DIFFRACTION / 解像度: 1.923 Å PDB-6g30: Crystal structure of the p97 D2 domain in a helical split-washer conformation 手法: X-RAY DIFFRACTION / 解像度: 2.418 Å |
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化合物 | ChemComp-EJQ: ~{N}-(4-fluorophenyl)-2-pyrrolidin-1-yl-ethanamide
ChemComp-ELQ: [3,4-bis(fluoranyl)phenyl]-(4-methylpiperazin-1-yl)methanone
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由来 | homo sapiens (ヒト)
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キーワード | HYDROLASE / ATPase / p97 / protein degradation |
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