EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
ジャーナル・号・ページ	Biochemistry, Vol. 57, Page 2876-2888, Year 2018
掲載日	2017年12月6日 (構造データの登録日)
著者	Prosdocimi, T. / Mollica, L. / Donini, S. / Semrau, M.S. / Lucarelli, A.P. / Aiolfi, E. / Cavalli, A. / Storici, P. / Alfei, S. / Brullo, C. ...Prosdocimi, T. / Mollica, L. / Donini, S. / Semrau, M.S. / Lucarelli, A.P. / Aiolfi, E. / Cavalli, A. / Storici, P. / Alfei, S. / Brullo, C. / Bruno, O. / Parisini, E.
リンク	Biochemistry / PubMed:29652483
手法	X線回折
解像度	1.45 - 2.1 Å
構造データ	PDB-6f6u: Crystal structure of the PDE4D catalytic domain in complex with GEBR-7b 手法: X-RAY DIFFRACTION / 解像度: 1.828 Å PDB-6f8r: Crystal structure of the PDE4D catalytic domain in complex with GEBR-54 手法: X-RAY DIFFRACTION / 解像度: 1.826 Å PDB-6f8t: Crystal structure of the PDE4D catalytic domain in complex with GEBR-4a 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6f8u: Crystal structure of the PDE4D catalytic domain in complex with GEBR-20b 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6f8v: Crystal structure of the PDE4D catalytic domain in complex with GEBR-18b 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6f8w: Crystal structure of the PDE4D catalytic domain in complex with GEBR-18a 手法: X-RAY DIFFRACTION / 解像度: 1.601 Å PDB-6f8x: Crystal structure of the PDE4D catalytic domain in complex with GEBR-26g 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6fdc: Crystal structure of the PDE4D catalytic domain in complex with GEBR-32a 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å
化合物	ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-ZN: Unknown entry ChemComp-CV8: 2-[(~{E})-(3-cyclopentyloxy-4-methoxy-phenyl)methylideneamino]oxy-1-[(2~{R},6~{S})-2,6-dimethylmorpholin-4-yl]ethanone ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-HOH: WATER ChemComp-CZK: (2~{S})-1-[3-(3-cyclopentyloxy-4-methoxy-phenyl)pyrazol-1-yl]-3-morpholin-4-yl-propan-2-ol ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-CZT: (2~{R})-1-[(~{E})-(3-cyclopentyloxy-4-methoxy-phenyl)methylideneamino]oxy-3-[(2~{R},6~{S})-2,6-dimethylmorpholin-4-yl]propan-2-ol ChemComp-CZQ: 2-[(~{E})-[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]methylideneamino]oxy-1-[(2~{R},6~{R})-2,6-dimethylmorpholin-4-yl]ethanone ChemComp-D0B: 3-[3-(3-cyclopentyloxy-4-methoxy-phenyl)pyrazol-1-yl]-1-[(2~{R},6~{R})-2,6-dimethylmorpholin-4-yl]propan-1-one ChemComp-D0E: 3-[3-(3-cyclopentyloxy-4-methoxy-phenyl)pyrazol-1-yl]-1-morpholin-4-yl-propan-1-one ChemComp-D08: 2-[(5~{R})-3-(3-cyclopentyloxy-4-methoxy-phenyl)-4,5-dihydro-1,2-oxazol-5-yl]-~{N},~{N}-bis(2-hydroxyethyl)ethanamide ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-DD5: (2~{R})-1-[3-[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]pyrazol-1-yl]-3-morpholin-4-yl-propan-2-ol ChemComp-D5N*: (2~{S})-1-[5-[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]pyrazol-1-yl]-3-morpholin-4-yl-propan-2-ol
由来	homo sapiens (ヒト)
キーワード	HYDROLASE / PDE4 / catalytic domain / inhibitor / GEBR