EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.
ジャーナル・号・ページ	J. Med. Chem., Vol. 62, Page 622-640, Year 2019
掲載日	2018年8月2日 (構造データの登録日)
著者	Vinh, N.B. / Drinkwater, N. / Malcolm, T.R. / Kassiou, M. / Lucantoni, L. / Grin, P.M. / Butler, G.S. / Duffy, S. / Overall, C.M. / Avery, V.M. ...Vinh, N.B. / Drinkwater, N. / Malcolm, T.R. / Kassiou, M. / Lucantoni, L. / Grin, P.M. / Butler, G.S. / Duffy, S. / Overall, C.M. / Avery, V.M. / Scammells, P.J. / McGowan, S.
リンク	J. Med. Chem. / PubMed:30537832
手法	X線回折
解像度	1.35 - 2.3 Å
構造データ	PDB-6ea1: X-ray crystal structure of Pf-M1 in complex with inhibitor (6da) and catalytic zinc ion 手法: X-RAY DIFFRACTION / 解像度: 1.815 Å PDB-6ea2: X-ray crystal structure of Pf-M1 in complex with inhibitor (6h) and catalytic zinc ion 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-6eaa: X-ray crystal structure of Pf-M1 in complex with inhibitor (6i) and catalytic zinc ion 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-6eab: X-ray crystal structure of Pf-M1 in complex with inhibitor (6j) and catalytic zinc ion 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6ee2: X-ray crystal structure of Pf-M17 in complex with inhibitor 6i and regulatory zinc ion 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6ee3: X-ray crystal structure of Pf-M1 in complex with inhibitor (6k) and catalytic zinc ion 手法: X-RAY DIFFRACTION / 解像度: 1.82 Å PDB-6ee4: X-ray crystal structure of Pf-M1 in complex with inhibitor (6m) and catalytic zinc ion 手法: X-RAY DIFFRACTION / 解像度: 1.58 Å PDB-6ee6: X-ray crystal structure of Pf-M1 in complex with inhibitor (6o) and catalytic zinc ion 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6eed: X-ray crystal structure of Pf-M1 in complex with inhibitor (6p) and catalytic zinc ion 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6eee: X-ray crystal structure of Pf-M17 in complex with inhibitor (6k) and regulatory zinc ion 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-J0Y: (2R)-2,3,3,3-tetrafluoro-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]propanamide ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-HOH: WATER ChemComp-J1G: N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]cyclopentanecarboxamide ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-J1V: N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]cyclohexanecarboxamide ChemComp-PO4: PHOSPHATE ION / ホスファ-ト ChemComp-J2D: N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]oxane-4-carboxamide ChemComp-CO3: CARBONATE ION / 炭酸ジアニオン ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-1PE: PENTAETHYLENE GLYCOL / ペンタエチレングリコ-ル / 沈殿剤YM ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-J4V: (1R,2r,3S,5R,7R)-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]tricyclo[3.3.1.1~3,7~]decane-2-carboxamide ChemComp-J4S: (2R)-2-[(cyclopropylacetyl)amino]-N-hydroxy-2-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)acetamide ChemComp-J4P: (2R)-2-[(cyclopentylacetyl)amino]-N-hydroxy-2-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)acetamide ChemComp-J6A: (2R)-2-[(cyclohexylacetyl)amino]-N-hydroxy-2-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)acetamide ChemComp-2PE: NONAETHYLENE GLYCOL / 3,6,9,12,15,18,21,24-オクタオキサヘキサコサン-1,26-ジオ-ル / 沈殿剤*YM
由来	plasmodium falciparum (isolate fcb1 / columbia) (マラリア病原虫) plasmodium falciparum nf135/5.c10 (マラリア病原虫) plasmodium falciparum (isolate hb3) (マラリア病原虫)
キーワード	hydrolase/hydrolase inhibitor / M1 ALANYL-AMINOPEPTIDASE / PROTEASE / INHIBITOR / HYDROXAMIC ACID / HYDROLASE / hydrolase-hydrolase inhibitor complex / M17 LEUCYL-AMINOPEPTIDASE