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-Structure paper
タイトル | Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure Based Drug Design. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 61, Page 11074-11100, Year 2018 |
掲載日 | 2018年7月31日 (構造データの登録日) |
![]() | Hobson, A.D. / Judge, R.A. / Aguirre, A.L. / Brown, B.S. / Cui, Y. / Ding, P. / Dominguez, E. / DiGiammarino, E. / Egan, D.A. / Freiberg, G.M. ...Hobson, A.D. / Judge, R.A. / Aguirre, A.L. / Brown, B.S. / Cui, Y. / Ding, P. / Dominguez, E. / DiGiammarino, E. / Egan, D.A. / Freiberg, G.M. / Gopalakrishnan, S.M. / Harris, C.M. / Honore, M.P. / Kage, K.L. / Kapecki, N.J. / Ling, C. / Ma, J. / Mack, H. / Mamo, M. / Maurus, S. / McRae, B. / Moore, N.S. / Mueller, B.K. / Mueller, R. / Namovic, M.T. / Patel, K. / Pratt, S.D. / Putman, C.B. / Queeney, K.L. / Sarris, K.K. / Schaffter, L.M. / Stoll, V.S. / Vasudevan, A. / Wang, L. / Wirthl, W. / Yach, K. |
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手法 | X線回折 |
解像度 | 1.88 - 2.96 Å |
構造データ | ![]() PDB-6e99: ![]() PDB-6e9l: ![]() PDB-6e9w: ![]() PDB-6ed6: |
化合物 | ![]() ChemComp-J0G: ![]() ChemComp-HOH: ![]() ChemComp-J0P: ![]() ChemComp-SO4: |
由来 |
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![]() | TRANSFERASE / Protein Kinase A / kinase / TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex / Rock1 / Rock 2 |