EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
ジャーナル・号・ページ	Cell Rep, Vol. 26, Page 2916-2928.e13, Year 2019
掲載日	2018年7月1日 (構造データの登録日)
著者	Aho, E.R. / Wang, J. / Gogliotti, R.D. / Howard, G.C. / Phan, J. / Acharya, P. / Macdonald, J.D. / Cheng, K. / Lorey, S.L. / Lu, B. ...Aho, E.R. / Wang, J. / Gogliotti, R.D. / Howard, G.C. / Phan, J. / Acharya, P. / Macdonald, J.D. / Cheng, K. / Lorey, S.L. / Lu, B. / Wenzel, S. / Foshage, A.M. / Alvarado, J. / Wang, F. / Shaw, J.G. / Zhao, B. / Weissmiller, A.M. / Thomas, L.R. / Vakoc, C.R. / Hall, M.D. / Hiebert, S.W. / Liu, Q. / Stauffer, S.R. / Fesik, S.W. / Tansey, W.P.
リンク	Cell Rep / PubMed:30865883
手法	X線回折
解像度	1.1 - 2.56 Å
構造データ	PDB-6dy7: WDR5 in complex with a WIN site inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6dya: WDR5 in complex with a WIN site inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.56 Å PDB-6e1y: Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design 手法: X-RAY DIFFRACTION / 解像度: 1.219 Å PDB-6e1z: Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity 手法: X-RAY DIFFRACTION / 解像度: 1.1 Å PDB-6e22: Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6e23: Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity 手法: X-RAY DIFFRACTION / 解像度: 1.66 Å
化合物	ChemComp-HH7: N-[3-(2,4-dichlorophenoxy)propyl]-1H-imidazol-2-amine ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM / ジメチルスルホキシド ChemComp-SO4: SULFATE ION / 硫酸ジアニオン / 硫酸塩 ChemComp-HOH: WATER / 水 ChemComp-HHM: N-[(3,5-dichlorophenyl)methyl]-3-[(1H-imidazol-1-yl)methyl]benzamide ChemComp-HLM: N-[(1S)-1-(3-chlorophenyl)ethyl]-3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}benzamide ChemComp-HLP: 5-[(1H-imidazol-1-yl)methyl]furan-2-carboxylic acid ChemComp-HLS: 3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}-N-[(3,5-dimethoxyphenyl)methyl]-4-fluorobenzamide ChemComp-HLJ: N-[(3,4-dichlorophenyl)methyl]-3-(6-fluoro-2-methylpyridin-3-yl)-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}benzamide ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤YM / HEPES
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE/TRANSFERASE inhibitor / WD40 repeat (WD40リピート) / epigenetic (エピジェネティクス) / WDR5-MLL / WIN site / TRANSFERASE-TRANSFERASE inhibitor complex / epigenetics (エピジェネティクス) / MLL binding / WIN site inhibitor / gene regulation/inhibitor / WDR5 / WIN-site / fragment screening / structure-based design / mixed-lineage leukemia / DNA BINDING PROTEIN (DNA結合タンパク質) / dna binding protein-inhibitor complex / GENE REGULATION (遺伝子発現の調節) / gene regulation-inhibitor complex