タイトル | Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 61, Page 8054-8060, Year 2018 |
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掲載日 | 2018年6月24日 (構造データの登録日) |
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著者 | Porter, N.J. / Osko, J.D. / Diedrich, D. / Kurz, T. / Hooker, J.M. / Hansen, F.K. / Christianson, D.W. |
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リンク | J. Med. Chem. / PubMed:30118224 |
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手法 | X線回折 |
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解像度 | 1.47 - 2.2 Å |
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構造データ | PDB-6dvl: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-115 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6dvm: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-122 手法: X-RAY DIFFRACTION / 解像度: 1.47 Å PDB-6dvn: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-137 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6dvo: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with Bavarostat 手法: X-RAY DIFFRACTION / 解像度: 1.98 Å |
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化合物 | ChemComp-BTB: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / ビストリス / pH緩衝剤*YM
ChemComp-HB7: N-[2-(benzylamino)-2-oxoethyl]-4-(dimethylamino)-N-{[4-(hydroxycarbamoyl)phenyl]methyl}benzamide
ChemComp-HBV: 3-fluoro-N-hydroxy-4-[(methyl{[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]methyl}amino)methyl]benzamide
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由来 | ![](img/tx_fish.gif) danio rerio (ゼブラフィッシュ)
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キーワード | hydrolase/hydrolase inhibitor / histone deacetylaase / metallohydrolase / hydrolase-hydrolase inhibitor complex / Histone deacetylase |
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