EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.
ジャーナル・号・ページ	J. Med. Chem., Vol. 62, Page 8480-8496, Year 2019
掲載日	2018年4月11日 (構造データの登録日)
著者	Pemberton, O.A. / Jaishankar, P. / Akhtar, A. / Adams, J.L. / Shaw, L.N. / Renslo, A.R. / Chen, Y.
リンク	J. Med. Chem. / PubMed:31483651
手法	X線回折
解像度	1.1 - 2.1 Å
構造データ	PDB-6d15: Crystal structure of KPC-2 complexed with compound 1 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-6d16: Crystal structure of KPC-2 complexed with compound 2 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-6d17: Crystal structure of KPC-2 complexed with compound 3 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-6d18: Crystal structure of KPC-2 complexed with compound 6 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-6d19: Crystal structure of KPC-2 complexed with compound 9 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-6d1a: Crystal structure of NDM-1 complexed with compound 1 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-6d1b: Crystal structure of NDM-1 complexed with compound 2 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-6d1c: Crystal structure of NDM-1 complexed with compound 3 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-6d1d: Crystal structure of NDM-1 complexed with compound 6 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-6d1e: Crystal structure of NDM-1 complexed with compound 7 手法: X-RAY DIFFRACTION / 解像度: 1.15 Å PDB-6d1f: Crystal structure of NDM-1 complexed with compound 8 手法: X-RAY DIFFRACTION / 解像度: 1.15 Å PDB-6d1g: Crystal structure of NDM-1 complexed with compound 9 手法: X-RAY DIFFRACTION / 解像度: 1.15 Å PDB-6d1h: Crystal structure of NDM-1 complexed with compound 11 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-6d1i: Crystal structure of NDM-1 complexed with compound 12 手法: X-RAY DIFFRACTION / 解像度: 1.1 Å PDB-6d1j: Crystal structure of NDM-1 complexed with compound 13 手法: X-RAY DIFFRACTION / 解像度: 1.15 Å PDB-6d1k: Crystal structure of NDM-1 complexed with compound 14 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-6dd0: Crystal structure of VIM-2 complexed with compound 8 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6dd1: Crystal structure of VIM-2 complexed with compound 14 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-6ny7: Crystal Structure of NDM-1 D199N with Compound 16 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-6o3r: Crystal Structure of NDM-1 D199N with Compound 7 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-6o5t: Crystal Structure of VIM-2 with Compound 16 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å
化合物	ChemComp-TWB: [(6,7-dimethyl-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid ChemComp-GOL: GLYCEROL / グリセロ-ル / グリセリン ChemComp-HOH: WATER / 水 ChemComp-FUJ: [(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid ChemComp-VKE: [(6-oxo-2H,6H-[1,3]dioxolo[4,5-g][1]benzopyran-8-yl)methyl]phosphonic acid ChemComp-GTV: [(5,7-dimethyl-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid ChemComp-YKG: [(5-bromo-7-methyl-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid ChemComp-ZN: Unknown entry ChemComp-ACT: ACETATE ION / 酢酸イオン / 酢酸塩 ChemComp-XJE: [(5-methoxy-7-methyl-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid ChemComp-P9T: [(5,7-difluoro-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid ChemComp-KED: [(2-oxo-1,2-dihydroquinolin-4-yl)methyl]phosphonic acid ChemComp-T6Z: [(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)methyl]phosphonic acid ChemComp-7SX: [(5,7-dimethyl-2-oxo-1,2-dihydroquinolin-4-yl)methyl]phosphonic acid ChemComp-M3Q: [(quinolin-8-yl)methyl]phosphonic acid ChemComp-L8J: [(5,7-dibromo-2-oxo-1,2-dihydroquinolin-4-yl)methyl]phosphonic acid
由来	klebsiella pneumoniae (肺炎桿菌) pseudomonas aeruginosa (緑膿菌)
キーワード	HYDROLASE/HYDROLASE inhibitor / beta-lactamase (Β-ラクタマーゼ) / carbapenemase (Β-ラクタマーゼ) / phosphonate / inhibitor (酵素阻害剤) / HYDROLASE (加水分解酵素) / HYDROLASE-HYDROLASE inhibitor complex / complex / HYDROLASE/INHIBITOR / HYDROLASE-INHIBITOR complex