EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
ジャーナル・号・ページ	J. Med. Chem., Vol. 61, Page 3516-3540, Year 2018
掲載日	2018年2月26日 (構造データの登録日)
著者	Reich, S.H. / Sprengeler, P.A. / Chiang, G.G. / Appleman, J.R. / Chen, J. / Clarine, J. / Eam, B. / Ernst, J.T. / Han, Q. / Goel, V.K. ...Reich, S.H. / Sprengeler, P.A. / Chiang, G.G. / Appleman, J.R. / Chen, J. / Clarine, J. / Eam, B. / Ernst, J.T. / Han, Q. / Goel, V.K. / Han, E.Z.R. / Huang, V. / Hung, I.N.J. / Jemison, A. / Jessen, K.A. / Molter, J. / Murphy, D. / Neal, M. / Parker, G.S. / Shaghafi, M. / Sperry, S. / Staunton, J. / Stumpf, C.R. / Thompson, P.A. / Tran, C. / Webber, S.E. / Wegerski, C.J. / Zheng, H. / Webster, K.R.
リンク	J. Med. Chem. / PubMed:29526098
手法	X線回折
解像度	2.8 - 3.6 Å
構造データ	PDB-6cj5: Crystal Structure of Mnk2-D228G in Complex With Inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-6cje: Crystal Structure of Mnk2-D228G in complex with Inhibitor 手法: X-RAY DIFFRACTION / 解像度: 3.36 Å PDB-6cjh: Co-crystal structure of MNK2 in complex with an inhibitor 手法: X-RAY DIFFRACTION / 解像度: 3.6 Å PDB-6cjw: Crystal Structure of Mnk2-D228G in Complex With Inhibitor 手法: X-RAY DIFFRACTION / 解像度: 3.38 Å PDB-6cjy: Crystal Structure of Mnk2-D228G in complex with Inhibitor 手法: X-RAY DIFFRACTION / 解像度: 3.05 Å PDB-6ck3: Co-crytsal Structure of MNK2 in Complex With an Inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-6ck6: Crystal Structure of Mnk2-D228G in complex with Inhibitor 手法: X-RAY DIFFRACTION / 解像度: 3.32 Å PDB-6cki: Co-crystal structure of MNK2 in Complex With Inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.95 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-F4G: 3-(pyridin-3-yl)imidazo[1,2-a]pyridine-8-carboxamide ChemComp-HOH: WATER ChemComp-F4A: 4-[(9H-purin-6-yl)amino]benzamide ChemComp-ET8: 3-phenyl-5-(pyridin-4-yl)-1H-indazole ChemComp-FYV: 3-(pyridin-4-yl)imidazo[1,2-b]pyridazine ChemComp-F4J: 5-[(7H-purin-6-yl)amino]-1H-isoindol-1-one ChemComp-F67: (3R)-3-methyl-5-[(pyrimidin-4-yl)amino]-2,3-dihydro-1H-isoindol-1-one ChemComp-CL: Unknown entry / クロリド ChemComp-N45: 6'-[(6-aminopyrimidin-4-yl)amino]-8'-methyl-2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione ChemComp-FZJ: 3,3-dimethyl-6-[(pyrimidin-4-yl)amino]-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dione
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE/TRANSFERASE Inhibitor / inhibitor kinase / TRANSFERASE-TRANSFERASE Inhibitor complex / mnk1 inhibitor / mnk2 inhibitor / TRANSFERASE / mnk2