タイトル | Crystallographic observation of nonenzymatic RNA primer extension. |
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ジャーナル・号・ページ | Elife, Vol. 7, Year 2018 |
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掲載日 | 2018年1月24日 (構造データの登録日) |
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著者 | Zhang, W. / Walton, T. / Li, L. / Szostak, J.W. |
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リンク | Elife / PubMed:29851379 |
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手法 | X線回折 |
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解像度 | 1.5 - 2.5 Å |
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構造データ | PDB-6c8d: RNA-dGMP complex with Mg ion 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-6c8e: RNA-imidazolium-bridged intermediate complex, 4h soaking 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6c8i: RNA-activated 2-AIpG monomer complex, 5 min soaking 手法: X-RAY DIFFRACTION / 解像度: 1.77 Å PDB-6c8j: RNA-activated 2-AIpG monomer complex, 15 min soaking 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6c8k: RNA-activated 2-AIpG monomer complex, 30 min soaking 手法: X-RAY DIFFRACTION / 解像度: 2.259 Å PDB-6c8l: RNA-activated 2-AIpG monomer complex, 1h soaking 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-6c8m: RNA-activated 2-AIpG monomer, 1.5h soaking 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-6c8n: RNA-activated 2-AIpG monomer complex, 2h soaking 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6c8o: RNA-activated 2-AIpG monomer, 3h soaking 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6cab: RNA-dGMP complex with Sr ion 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
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化合物 | ChemComp-EQ1: [2-azanyl-3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]imidazol-1-yl]-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy]phosphinic acid
ChemComp-EQ4: 5'-O-[(R)-(2-amino-1H-imidazol-1-yl)(hydroxy)phosphoryl]guanosine
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由来 | - synthetic construct (人工物)
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キーワード | RNA / deoxyguanosine / intermediate / dinucleotide / activated monomer |
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