タイトル | The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis. |
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ジャーナル・号・ページ | J. Biol. Chem., Vol. 293, Page 3236-3251, Year 2018 |
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掲載日 | 2017年11月2日 (構造データの登録日) |
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著者 | Ting, Y.T. / Petersen, J. / Ramarathinam, S.H. / Scally, S.W. / Loh, K.L. / Thomas, R. / Suri, A. / Baker, D.G. / Purcell, A.W. / Reid, H.H. / Rossjohn, J. |
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リンク | J. Biol. Chem. / PubMed:29317506 |
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手法 | X線回折 |
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解像度 | 2.05004900063 - 2.9 Å |
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構造データ | PDB-6bij: HLA-DRB1 in complex with citrullinated fibrinogen peptide 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6bil: HLA-DRB1 in complex with citrullinated fibrinogen peptide 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-6bin: HLA-DRB1 in complex with Type II collagen peptide 手法: X-RAY DIFFRACTION / 解像度: 2.50000845062 Å PDB-6bir: HLA-DRB1 in complex with citrullinated Vimentin peptide 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-6biv: HLA-DRB1 in complex with citrullinated LL37 peptide 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-6bix: HLA-DRB1 in complex with citrullinated LL37 peptide 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6biy: HLA-DRB1 in complex with Histone 2B peptide 手法: X-RAY DIFFRACTION / 解像度: 2.05004900063 Å PDB-6biz: HLA-DRB1 in complex with citrullinated Histone 2B peptide 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å |
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化合物 | |
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由来 | ![](img/tx_human.gif) homo sapiens (ヒト)
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キーワード | IMMUNE SYSTEM (免疫系) / HLA / MHC / citrulline (シトルリン) / Rheumatoid Arthritis (関節リウマチ) |
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