タイトル | Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. |
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ジャーナル・号・ページ | Nucleic Acids Res., Vol. 46, Page 11990-12007, Year 2018 |
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掲載日 | 2017年10月20日 (構造データの登録日) |
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著者 | McMurrough, T.A. / Brown, C.M. / Zhang, K. / Hausner, G. / Junop, M.S. / Gloor, G.B. / Edgell, D.R. |
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リンク | Nucleic Acids Res. / PubMed:30357419 |
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手法 | X線回折 |
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解像度 | 1.75 - 2.92 Å |
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構造データ | PDB-6bce: Wild-type I-LtrI bound to cognate substrate (pre-cleavage complex) 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-6bcf: I-LtrI G183A bound to cognate substrate (pre-cleavage complex) 手法: X-RAY DIFFRACTION / 解像度: 2.92 Å PDB-6bcg: I-LtrI A28G bound to cognate substrate (pre-cleavage complex) 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-6bci: Wild-type I-LtrI bound to non-cognate C4 substrate (pre-cleavage complex) 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-6bcn: I-LtrI E184D bound to cognate substrate (pre-cleavage complex) 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-6bct: I-LtrI E184D bound to non-cognate C4 substrate (pre-cleavage complex) 手法: X-RAY DIFFRACTION / 解像度: 2.73 Å |
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化合物 | |
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由来 | leptographium truncatum (菌類)
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キーワード | HYDROLASE/DNA / Nucleic Acid / HYDROLASE / HYDROLASE-DNA complex / Nucleic Acd |
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