タイトル | A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad. |
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ジャーナル・号・ページ | Sci Adv, Vol. 4, Page eaas8667-eaas8667, Year 2018 |
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掲載日 | 2017年10月19日 (構造データの登録日) |
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著者 | Kumar, P. / Serpersu, E.H. / Cuneo, M.J. |
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リンク | Sci Adv / PubMed:29632894 |
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手法 | X線回折 / 中性子線回折 |
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解像度 | 1.8 - 2.2 Å |
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構造データ | PDB-6bbr: Room temperature neutron/X-ray structure of AAC-VIa 手法: X-RAY DIFFRACTION / NEUTRON DIFFRACTION / 解像度: 2.002 Å PDB-6bbz: Room temperature neutron/X-ray structure of sisomicin bound AAC-VIa 手法: X-RAY DIFFRACTION / NEUTRON DIFFRACTION / 解像度: 1.9 Å PDB-6bc2: Cryo X-ray structure of acetylsisomicin bound AAC-VIa 手法: X-RAY DIFFRACTION / 解像度: 2.195 Å PDB-6bc3: Cryo X-ray structure of sisomicin bound AAC-VIa 手法: X-RAY DIFFRACTION / 解像度: 2.047 Å PDB-6bc4: Cryo X-ray structure of acetyl coenzyme A bound AAC-VIa 手法: X-RAY DIFFRACTION / 解像度: 2.049 Å PDB-6bc5: Cryo X-ray structure of coenzyme A bound AAC-VIa 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6bc6: Cryo X-ray structure of apo AAC-VIa 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6bc7: Cryo X-ray structure of sisomicin bound AAC-VIa 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å |
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化合物 | ChemComp-SIS: (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside / シソマイシン / 抗生剤*YM
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由来 | enterobacter cloacae (バクテリア)
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キーワード | TRANSFERASE / acetyltransferase / TRANSFERASE/ANTIBIOTIC / TRANSFERASE-ANTIBIOTIC complex / sisomicin |
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