タイトル | Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum? |
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ジャーナル・号・ページ | Int. J. Parasitol., Year 2020 |
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掲載日 | 2017年9月27日 (構造データの登録日) |
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著者 | Rugel, A.R. / Guzman, M.A. / Taylor, A.B. / Chevalier, F.D. / Tarpley, R.S. / McHardy, S.F. / Cao, X. / Holloway, S.P. / Anderson, T.J.C. / Hart, P.J. / LoVerde, P.T. |
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リンク | Int. J. Parasitol. / PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.46 - 2.05 Å |
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構造データ | PDB-6b4x: Schistosoma mansoni (Blood Fluke) Sulfotransferase, F39Y Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.46 Å PDB-6b4y: Schistosoma mansoni (Blood Fluke) Sulfotransferase/Oxamniquine Complex, F39Y Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6b4z: Schistosoma mansoni (Blood Fluke) Sulfotransferase, T157S Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.74 Å PDB-6b50: Schistosoma mansoni (Blood Fluke) Sulfotransferase/Oxamniquine Complex, T157S Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-6b51: Schistosoma haematobium (Blood Fluke) Sulfotransferase, Y54F Mutant 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-6b52: Schistosoma haematobium (Blood Fluke) Sulfotransferase/Oxamniquine Complex, Y54F Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6b53: Schistosoma haematobium (Blood Fluke) Sulfotransferase, S166T Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6b54: Schistosoma haematobium (Blood Fluke) Sulfotransferase/Oxamniquine Complex, S166T Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å |
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化合物 | ChemComp-OAQ: {(2S)-7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl}methanol / 薬剤*YM
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由来 | - schistosoma mansoni (マンソン住血吸虫)
- schistosoma haematobium (ビルハルツ住血吸虫)
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キーワード | TRANSFERASE / sulfotransferase / parasite / drug resistance / helminth |
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