タイトル | Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase. |
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ジャーナル・号・ページ | ACS Chem. Biol., Vol. 13, Page 3173-3183, Year 2018 |
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掲載日 | 2017年9月8日 (構造データの登録日) |
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著者 | Ducati, R.G. / Harijan, R.K. / Cameron, S.A. / Tyler, P.C. / Evans, G.B. / Schramm, V.L. |
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リンク | ACS Chem. Biol. / PubMed:30339406 |
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手法 | X線回折 |
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解像度 | 1.25 - 1.95 Å |
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構造データ | PDB-6aym: Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-6ayo: Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with 5'-deoxy-5'-Propyl-DADMe-Immucillin-A 手法: X-RAY DIFFRACTION / 解像度: 1.67 Å PDB-6ayq: Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with methylthio-DADMe-Immucillin-A 手法: X-RAY DIFFRACTION / 解像度: 1.42 Å PDB-6ayr: Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with butylthio-DADMe-Immucillin-A 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6ays: Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with hexylthio-DADMe-Immucillin-A 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-6ayt: Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with pyrazinylthio-DADMe-Immucillin-A 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å |
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化合物 | ChemComp-C1Y: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-propylpyrrolidin-3-ol
ChemComp-BTB: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / ビストリス / pH緩衝剤*YM
ChemComp-HT6: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(hexylsulfanyl)methyl]pyrrolidin-3-ol
ChemComp-4EH: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(pyrazin-2-ylsulfanyl)methyl]pyrrolidin-3-ol
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由来 | ![](img/tx_bacteria.gif) campylobacter jejuni (カンピロバクター)
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キーワード | HYDROLASE / TRANSFERASE / MTAN enzyme / Foodborne Diseases |
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