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-Structure paper
タイトル | An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. |
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ジャーナル・号・ページ | Science, Vol. 362, Issue 6418, Year 2018 |
掲載日 | 2018年11月30日 |
著者 | Hongri Gong / Jun Li / Ao Xu / Yanting Tang / Wenxin Ji / Ruogu Gao / Shuhui Wang / Lu Yu / Changlin Tian / Jingwen Li / Hsin-Yung Yen / Sin Man Lam / Guanghou Shui / Xiuna Yang / Yuna Sun / Xuemei Li / Minze Jia / Cheng Yang / Biao Jiang / Zhiyong Lou / Carol V Robinson / Luet-Lok Wong / Luke W Guddat / Fei Sun / Quan Wang / Zihe Rao / |
PubMed 要旨 | We report a 3.5-angstrom-resolution cryo-electron microscopy structure of a respiratory supercomplex isolated from It comprises a complex III dimer flanked on either side by individual complex IV ...We report a 3.5-angstrom-resolution cryo-electron microscopy structure of a respiratory supercomplex isolated from It comprises a complex III dimer flanked on either side by individual complex IV subunits. Complex III and IV associate so that electrons can be transferred from quinol in complex III to the oxygen reduction center in complex IV by way of a bridging cytochrome subunit. We observed a superoxide dismutase-like subunit at the periplasmic face, which may be responsible for detoxification of superoxide formed by complex III. The structure reveals features of an established drug target and provides a foundation for the development of treatments for human tuberculosis. |
リンク | Science / PubMed:30361386 |
手法 | EM (単粒子) |
解像度 | 3.5 Å |
構造データ | |
化合物 | ChemComp-CU: ChemComp-HEA: ChemComp-CDL: ChemComp-9Y0: ChemComp-PLM: ChemComp-9XX: ChemComp-9YF: ChemComp-HEM: ChemComp-MQ9: ChemComp-HEC: ChemComp-FES: |
由来 |
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キーワード | ELECTRON TRANSPORT / Respiratory / Supercomplex / SOD / Mycobacterium / ETC / Lipoprotein |