タイトル | Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions. |
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ジャーナル・号・ページ | Front Pharmacol, Vol. 9, Page 997-997, Year 2018 |
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掲載日 | 2018年3月2日 (構造データの登録日) |
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著者 | Miyazaki, Y. / Inaoka, D.K. / Shiba, T. / Saimoto, H. / Sakura, T. / Amalia, E. / Kido, Y. / Sakai, C. / Nakamura, M. / Moore, A.L. ...Miyazaki, Y. / Inaoka, D.K. / Shiba, T. / Saimoto, H. / Sakura, T. / Amalia, E. / Kido, Y. / Sakai, C. / Nakamura, M. / Moore, A.L. / Harada, S. / Kita, K. |
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リンク | Front Pharmacol / PubMed:30233375 |
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手法 | X線回折 |
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解像度 | 1.66 - 2 Å |
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構造データ | PDB-5zf4: Structure of human dihydroorotate dehydrogenase in complex with 275-10-COOMe 手法: X-RAY DIFFRACTION / 解像度: 1.66 Å PDB-5zf7: Structure of human dihydroorotate dehydrogenase in complex with 277-9-OH 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å PDB-5zf8: Structure of human dihydroorotate dehydrogenase in complex with 277-11-OAc 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-5zf9: Structure of human dihydroorotate dehydrogenase in complex with 280-12 手法: X-RAY DIFFRACTION / 解像度: 1.77 Å PDB-5zfa: Structure of human dihydroorotate dehydrogenase in complex with 287-12-OCOiPr 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-5zfb: Structure of human dihydroorotate dehydrogenase in complex with ascofuranone (open-form) 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å |
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化合物 | ChemComp-9BL: methyl (2E,6E)-8-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-2,6-dimethylocta-2,6-dienoate
ChemComp-CHW: 3-chloro-4,6-dihydroxy-5-[(2E,6E,8S)-8-hydroxy-3,7-dimethylnona-2,6-dien-1-yl]-2-methylbenzaldehyde
ChemComp-9BO: (2S,3E,7E)-9-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,7-dimethylnona-3,7-dien-2-yl acetate
ChemComp-9BR: 3-chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzaldehyde / LL-Z1272α
ChemComp-9BU: (2E,6E)-8-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,6-dimethylocta-2,6-dien-1-yl 2-methylpropanoate
ChemComp-9BX: 3-chloro-4,6-dihydroxy-5-[(2Z,6Z,8E)-11-hydroxy-3,7,11-trimethyl-10-oxododeca-2,6,8-trien-1-yl]-2-methylbenzaldehyde
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由来 | homo sapiens (ヒト)
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キーワード | OXIDOREDUCTASE / ROSSMANN FOLD / DIHYDROOROTATE/OROTATE / UBIQUINONE/UBIQUINOL / MITOCHONDRIAL INNER MEMBRANE / INHIBITOR COMPLEX |
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