タイトル | The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis. |
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ジャーナル・号・ページ | Nat Commun, Vol. 8, Page 2242-2242, Year 2017 |
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掲載日 | 2017年11月1日 (構造データの登録日) |
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著者 | Feng, H. / Liu, X. / Wang, S. / Fleming, J. / Wang, D.C. / Liu, W. |
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リンク | Nat Commun / PubMed:29269938 |
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手法 | X線回折 |
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解像度 | 1.8 - 2.3 Å |
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構造データ | PDB-5ypi: Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EI1 complex 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-5ypk: Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EI2 complex 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5ypl: Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EP complex 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-5ypm: Crystal structure of NDM-1 bound to hydrolyzed meropenem representing an EI1 complex 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-5ypn: Crystal structure of NDM-1 bound to hydrolyzed meropenem representing an EI2 complex 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å |
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化合物 | ChemComp-HIW: (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca
ChemComp-8YL: (2S,3R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfan / 抗生剤*YM
ChemComp-LMP: (2~{S},3~{R},4~{S})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-(dimethylcarbamoy
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由来 | ![](img/tx_bacteria.gif) escherichia coli (大腸菌)
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キーワード | HYDROLASE / NDM-1 / Imipenem / EI1 complex / EI2 complex / EP complex / meropenem / MDM-1 |
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