Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
PDB-5wkj: 2.05 A resolution structure of MERS 3CL protease in complex with inhibitor GC376 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å
PDB-5wkk: 1.55 A resolution structure of MERS 3CL protease in complex with inhibitor GC813 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å
PDB-5wkl: 1.85 A resolution structure of MERS 3CL protease in complex with piperidine-based peptidomimetic inhibitor 17 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å
PDB-5wkm: 2.25 A resolution structure of MERS 3CL protease in complex with piperidine-based peptidomimetic inhibitor 21 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å