タイトル | Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. U.S.A., Vol. 114, Page E2563-E2570, Year 2017 |
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掲載日 | 2016年12月3日 (構造データの登録日) |
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著者 | Wu, C.C. / Baiga, T.J. / Downes, M. / La Clair, J.J. / Atkins, A.R. / Richard, S.B. / Fan, W. / Stockley-Noel, T.A. / Bowman, M.E. / Noel, J.P. / Evans, R.M. |
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リンク | Proc. Natl. Acad. Sci. U.S.A. / PubMed:28320959 |
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手法 | X線回折 |
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解像度 | 1.5 - 2.15 Å |
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構造データ | PDB-5u3q: Human PPARdelta ligand-binding domain in complexed with specific agonist 1 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-5u3r: Human PPARdelta ligand-binding domain in complexed with specific agonist 2 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-5u3s: Human PPARdelta ligand-binding domain in complexed with specific agonist 3 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5u3t: Human PPARdelta ligand-binding domain in complexed with specific agonist 4 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-5u3u: Human PPARdelta ligand-binding domain in complexed with specific agonist 5 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-5u3v: Human PPARdelta ligand-binding domain in complexed with specific agonist 6 手法: X-RAY DIFFRACTION / 解像度: 1.84 Å PDB-5u3w: Human PPARdelta ligand-binding domain in complexed with specific agonist 7 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-5u3x: Human PPARdelta ligand-binding domain in complexed with specific agonist 8 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-5u3y: Human PPARdelta ligand-binding domain in complexed with specific agonist 9 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5u3z: Human PPARdelta ligand-binding domain in complexed with specific agonist 10 手法: X-RAY DIFFRACTION / 解像度: 1.72 Å PDB-5u40: Human PPARdelta ligand-binding domain in complexed with specific agonist 15 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5u41: Human PPARdelta ligand-binding domain in complexed with specific agonist 16 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5u42: Human PPARdelta ligand-binding domain in complexed with specific agonist 11 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-5u43: Human PPARdelta ligand-binding domain in complexed with specific agonist 12 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5u44: Human PPARdelta ligand-binding domain in complexed with specific agonist 13 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-5u45: Human PPARdelta ligand-binding domain in complexed with specific agonist 14 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-5u46: Human PPARdelta ligand-binding domain in complexed with GW501516 手法: X-RAY DIFFRACTION / 解像度: 2 Å |
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化合物 | ChemComp-7UJ: 6-(2-{[([1,1'-biphenyl]-4-carbonyl)(propan-2-yl)amino]methyl}phenoxy)hexanoic acid
ChemComp-7V1: 6-[2-({[4-(furan-2-yl)benzene-1-carbonyl](propan-2-yl)amino}methyl)phenoxy]hexanoic acid
ChemComp-7V4: 6-[2-({[4-(furan-3-yl)benzene-1-carbonyl](propan-2-yl)amino}methyl)phenoxy]hexanoic acid
ChemComp-7UY: 6-[2-({(propan-2-yl)[4-(thiophen-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid
ChemComp-7TV: 6-[2-({cyclopentyl[4-(furan-2-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid
ChemComp-7TY: 6-[2-({cyclopentyl[4-(furan-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid
ChemComp-7U1: 6-(2-{[([1,1'-biphenyl]-4-carbonyl)(cyclopropyl)amino]methyl}phenoxy)hexanoic acid
ChemComp-7U4: 6-[2-({cyclopropyl[4-(pyridin-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid
ChemComp-7U7: 6-[2-({cyclopropyl[4-(furan-2-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid
ChemComp-7UA: 6-[2-({cyclopropyl[4-(furan-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid
ChemComp-7UD: 6-[2-({benzyl[4-(furan-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid
ChemComp-7UG: 6-[2-({benzyl[4-(thiophen-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid
ChemComp-7SM: 6-(2-{[cyclopropyl(3'-methoxy[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid
ChemComp-7SS: 6-(2-{[cyclopropyl(4'-methoxy[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid
ChemComp-7SV: 6-(2-{[cyclopropyl(2'-fluoro[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid
ChemComp-7SY: 6-(2-{[cyclopropyl(3'-fluoro[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid
ChemComp-7T1: {2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid / GW-501516 / アゴニスト*YM
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由来 | homo sapiens (ヒト)
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キーワード | protein binding/activator / PPARdelta / ligand-binding domain / agonist / protein binding-activator complex / GW501516 |
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