タイトル | Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain. |
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ジャーナル・号・ページ | Eur J Med Chem, Vol. 134, Page 86-96, Year 2017 |
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掲載日 | 2017年4月3日 (構造データの登録日) |
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著者 | Belorusova, A.Y. / Martinez, A. / Gandara, Z. / Gomez, G. / Fall, Y. / Rochel, N. |
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リンク | Eur J Med Chem / PubMed:28399453 |
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手法 | X線回折 |
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解像度 | 2.096 - 2.8 Å |
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構造データ | PDB-5nky: Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain 手法: X-RAY DIFFRACTION / 解像度: 2.096 Å PDB-5nma: Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-5nmb: Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
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化合物 | ChemComp-91W: (1~{R},3~{S},5~{Z})-5-[(2~{E})-2-[(1~{R},3~{a}~{S},7~{a}~{R})-7~{a}-methyl-1-[(1~{S})-1-[(2~{R},5~{S})-5-(2-oxidanylpropan-2-yl)oxolan-2-yl]ethyl]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
ChemComp-9CW: (1~{R},3~{S},5~{Z})-5-[(2~{E})-2-[(1~{R},3~{a}~{S},7~{a}~{R})-7~{a}-methyl-1-[(1~{S})-1-[(2~{S},5~{S})-5-(2-oxidanylpropan-2-yl)oxolan-2-yl]ethyl]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol / (5Z,7E,20S)-20-[(2S)-5β-(1-ヒドロキシ-1-メチルエチル)テトラヒドロフラン-2α-イル]-(以下略)
ChemComp-9CZ: (1~{R},3~{S},5~{Z})-5-[(2~{E})-2-[(1~{R},3~{a}~{S},7~{a}~{R})-7~{a}-methyl-1-[(1~{S})-1-[(2~{S},5~{R})-5-(2-oxidanylpropan-2-yl)oxolan-2-yl]ethyl]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol / (5Z,7E,20S)-20-[(2S)-5α-(1-ヒドロキシ-1-メチルエチル)テトラヒドロフラン-2α-イル]-(以下略)
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由来 | ![](img/tx_fish.gif) danio rerio (ゼブラフィッシュ) homo sapiens (ヒト)
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キーワード | GENE REGULATION / TRANSCRIPTION / vitamin D nuclear receptor / transcription factor / transcriotion |
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