タイトル | Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. |
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ジャーナル・号・ページ | ACS Med Chem Lett, Vol. 9, Page 929-934, Year 2018 |
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掲載日 | 2015年10月29日 (構造データの登録日) |
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著者 | Zhu, J. / Dong, J. / Batiste, L. / Unzue, A. / Dolbois, A. / Pascanu, V. / Sledz, P. / Nevado, C. / Caflisch, A. |
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リンク | ACS Med Chem Lett / PubMed:30258543 |
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手法 | X線回折 |
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解像度 | 1.198 - 2.1 Å |
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構造データ | PDB-5eic: Crystal structure of the bromodomain of human CREBBP in complex with AYC 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-5eng: Crystal structure of the bromodomain of human CREBBP in complex with UP39 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-5ep7: Crystal structure of the bromodomain of human CREBBP in complex with UN32 手法: X-RAY DIFFRACTION / 解像度: 1.198 Å PDB-5h85: Crystal structure of the bromodomain of human CREBBP in complex with UO37D 手法: X-RAY DIFFRACTION / 解像度: 1.701 Å PDB-5mme: Crystal structure of CREBBP bromodomain complexd with US46C 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-5mmg: Crystal structure of CREBBP bromodomain complexed with UT07C 手法: X-RAY DIFFRACTION / 解像度: 1.23 Å PDB-5mpk: Crystal structure of CREBBP bromodomain complexed with DK19 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5mpn: Crystal structure of CREBBP bromodomain complexed with FA26 手法: X-RAY DIFFRACTION / 解像度: 1.23 Å PDB-5owk: Crystal structure of CREBBP bromodomain complexed with DSPB2A002 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-6fqo: Crystal structure of CREBBP bromodomain complexd with DT29 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-6fqu: Crystal structure of CREBBP bromodomain complexd with DR09 手法: X-RAY DIFFRACTION / 解像度: 1.43 Å PDB-6fr0: Crystal structure of CREBBP bromodomain complexd with PB08 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6frf: Crystal structure of CREBBP bromodomain complexd with PA10 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å |
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化合物 | ChemComp-5J5: 2-[(chloroacetyl)amino]-5-[(E)-(4-sulfophenyl)diazenyl]benzenesulfonic acid
ChemComp-5QN: methyl 2-[2-(3,5-dihydro-2~{H}-pyrazin-4-yl)ethoxy]-5-[(5-ethanoyl-2-ethoxy-phenyl)carbamoyl]benzoate
ChemComp-5QR: 3-[(1-methyl-6-oxidanylidene-pyridin-3-yl)carbonylamino]benzoic acid
ChemComp-5XS: methyl 3-(7~{H}-purin-6-ylcarbamoyl)benzoate
ChemComp-8Q6: dimethyl 5-[(5-ethanoyl-2-ethoxy-phenyl)amino]benzene-1,3-dicarboxylate
ChemComp-UT0: 1-[4-ethoxy-3-[(1-methylsulfonylindol-6-yl)amino]phenyl]ethanone
ChemComp-0BC: ~{N}-(5-ethanoyl-2-ethoxy-phenyl)-3-(2~{H}-1,2,3,4-tetrazol-5-yl)-5-(1,3-thiazol-4-yl)benzamide
ChemComp-YE5: 1-[4-ethoxy-3-[3-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]ethanone
ChemComp-7MX: ethyl 4-chloranyl-1-methyl-6-oxidanylidene-pyridine-3-carboxylate
ChemComp-E2T: ~{N}-[3-(2,5-dimethyl-3-oxidanylidene-1,2-oxazol-4-yl)-5-(5-ethanoyl-2-ethoxy-phenyl)phenyl]furan-2-carboxamide
ChemComp-E3B: 1-[3-[3-[3,3-bis(fluoranyl)piperidin-1-yl]phenyl]-4-ethoxy-phenyl]ethanone
ChemComp-E3H: ~{N}-[3-(5-ethanoyl-2-ethoxy-phenyl)-5-(2-ethyl-5-methyl-3-oxidanylidene-1,2-oxazol-4-yl)phenyl]furan-2-carboxamide
ChemComp-E3T: ~{N}-[3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-(5-ethanoyl-2-ethoxy-phenyl)phenyl]furan-2-carboxamide
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSFERASE / Transferase-Inhibitor complex / Transcription / INHIBITOR / Bromodomain / CREBBP bromodomain |
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