Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
PDB-5mkx: 1.68A STRUCTURE PCAF BROMODOMAIN WITH 4-chloro-2-methyl-5-(methylamino)pyridazin-3(2H)-one 手法: X-RAY DIFFRACTION / 解像度: 1.68 Å
PDB-5mky: BROMODOMAIN OF HUMAN BRD9 WITH 4-chloro-2-methyl-5-((2-methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)amino)pyridazin-3(2H)-one 手法: X-RAY DIFFRACTION / 解像度: 1.67 Å
PDB-5mkz: N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 4-chloro-2-methyl-5-(((3-methylthiophen-2-yl)methyl)amino)pyridazin-3(2H)-one 手法: X-RAY DIFFRACTION / 解像度: 1.62 Å
PDB-5ml0: Bromodomain of Mouse PCAF with (R)-4-chloro-2-methyl-5-((1-methylpiperidin-3-yl)amino)pyridazin-3(2H)-one 手法: X-RAY DIFFRACTION / 解像度: 1.64 Å
PDB-5mli: N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 4-chloro-2-methyl-5-(methylamino)pyridazin-3(2H)-one 手法: X-RAY DIFFRACTION / 解像度: 1.63 Å
PDB-5mlj: Bromodomain of Human GCN5 with 4-bromo-2-methyl-5-(((3R,5R)-1-methyl-5-phenylpiperidin-3-yl)amino)pyridazin-3(2H)-one 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å