EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	The structure and flexibility of conical HIV-1 capsids determined within intact virions.
ジャーナル・号・ページ	Science, Vol. 354, Issue 6318, Page 1434-1437, Year 2016
掲載日	2016年12月16日
著者	Simone Mattei / Bärbel Glass / Wim J H Hagen / Hans-Georg Kräusslich / John A G Briggs /
PubMed 要旨	HIV-1 contains a cone-shaped capsid encasing the viral genome. This capsid is thought to follow fullerene geometry-a curved hexameric lattice of the capsid protein, CA, closed by incorporating 12 CA ...HIV-1 contains a cone-shaped capsid encasing the viral genome. This capsid is thought to follow fullerene geometry-a curved hexameric lattice of the capsid protein, CA, closed by incorporating 12 CA pentamers. Current models for core structure are based on crystallography of hexameric and cross-linked pentameric CA, electron microscopy of tubular CA arrays, and simulations. Here, we report subnanometer-resolution cryo-electron tomography structures of hexameric and pentameric CA within intact HIV-1 particles. Whereas the hexamer structure is compatible with crystallography studies, the pentamer forms using different interfaces. Determining multiple structures revealed how CA flexes to form the variably curved core shell. We show that HIV-1 CA assembles both aberrant and perfect fullerene cones, supporting models in which conical cores assemble de novo after maturation.
リンク	Science / PubMed:27980210
手法	EM (トモグラフィー) / EM (サブトモグラム平均)
解像度	6.8 - 8.8 Å
構造データ	EMDB-3464: Cryo-electron tomogram containing mature HIV-1 particles 手法: EM (トモグラフィー) 3465 5mcx EMDB-3465, PDB-5mcx: The structure of the mature HIV-1 CA hexamer in intact virus particles 手法: EM (サブトモグラム平均) / 解像度: 6.8 Å 3466 5mcy EMDB-3466, PDB-5mcy: The structure of the mature HIV-1 CA pentamer in intact virus particles 手法: EM (サブトモグラム平均) / 解像度: 8.8 Å 3467 5mcz EMDB-3467, PDB-5mcz: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=-1, twist=0 手法: EM (サブトモグラム平均) / 解像度: 8.2 Å 3468 5md0 EMDB-3468, PDB-5md0: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=5, twist=6 手法: EM (サブトモグラム平均) / 解像度: 8.4 Å 3469 5md1 EMDB-3469, PDB-5md1: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=5, twist=0 手法: EM (サブトモグラム平均) / 解像度: 8.2 Å 3470 5md2 EMDB-3470, PDB-5md2: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=5, twist=-6 手法: EM (サブトモグラム平均) / 解像度: 8.6 Å 3471 5md3 EMDB-3471, PDB-5md3: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=11, twist=12 手法: EM (サブトモグラム平均) / 解像度: 8.5 Å 3472 5md4 EMDB-3472, PDB-5md4: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=11, twist=6 手法: EM (サブトモグラム平均) / 解像度: 8.4 Å 3473 5md5 EMDB-3473, PDB-5md5: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=11, twist=0 手法: EM (サブトモグラム平均) / 解像度: 8.2 Å 3474 5md6 EMDB-3474, PDB-5md6: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=11, twist=-6 手法: EM (サブトモグラム平均) / 解像度: 8.1 Å 3475 5md7 EMDB-3475, PDB-5md7: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=11, twist=-12 手法: EM (サブトモグラム平均) / 解像度: 8.4 Å 3477 5md8 EMDB-3477, PDB-5md8: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=17, twist=12 手法: EM (サブトモグラム平均) / 解像度: 8.6 Å 3478 5md9 EMDB-3478, PDB-5md9: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=17, twist=6 手法: EM (サブトモグラム平均) / 解像度: 8.0 Å 3479 5mda EMDB-3479, PDB-5mda: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=17, twist=0 手法: EM (サブトモグラム平均) / 解像度: 8.4 Å 3480 5mdb EMDB-3480, PDB-5mdb: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=17, twist=-6 手法: EM (サブトモグラム平均) / 解像度: 8.4 Å 3481 5mdc EMDB-3481, PDB-5mdc: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=17, twist=-12 手法: EM (サブトモグラム平均) / 解像度: 8.4 Å 3482 5mdd EMDB-3482, PDB-5mdd: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=23, twist=6 手法: EM (サブトモグラム平均) / 解像度: 8.5 Å 3483 5mde EMDB-3483, PDB-5mde: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=23, twist=0 手法: EM (サブトモグラム平均) / 解像度: 8.4 Å 3484 5mdf EMDB-3484, PDB-5mdf: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=23, twist=-6 手法: EM (サブトモグラム平均) / 解像度: 8.5 Å 3485 5mdg EMDB-3485, PDB-5mdg: The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=29, twist=0 手法: EM (サブトモグラム平均) / 解像度: 8.7 Å
由来	human immunodeficiency virus 1 (ヒト免疫不全ウイルス)
キーワード	VIRAL PROTEIN / retrovirus / HIV-1 / capsid / hexamer / pentamer / lattice curvature