タイトル | Structural basis of pyrrole polymerization in human porphobilinogen deaminase. |
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ジャーナル・号・ページ | Biochim Biophys Acta Gen Subj, Vol. 1862, Page 1948-1955, Year 2018 |
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掲載日 | 2016年10月25日 (構造データの登録日) |
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著者 | Pluta, P. / Roversi, P. / Bernardo-Seisdedos, G. / Rojas, A.L. / Cooper, J.B. / Gu, S. / Pickersgill, R.W. / Millet, O. |
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リンク | Biochim Biophys Acta Gen Subj / PubMed:29908816 |
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手法 | X線回折 |
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解像度 | 2.73 - 2.78 Å |
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構造データ | PDB-5m6r: Human porphobilinogen deaminase in complex with reaction intermediate 手法: X-RAY DIFFRACTION / 解像度: 2.73 Å PDB-5m7f: Human porphobilinogen deaminase in complex with DPM cofactor 手法: X-RAY DIFFRACTION / 解像度: 2.78 Å |
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化合物 | ChemComp-7J8: 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid
ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤*YM
ChemComp-DPM: 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / Porphobilinogen deaminase / heme biosynthesis / porphyria / HMBS |
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